POST-DOCTORAL TRAINING IN CARDIOVASCULAR DISEASE

这项申请申请资金，以建立一个多学科 心血管机制博士后培训计划 专注于将外科实习生吸引到基础实验室的疾病 调查。该计划的基本原理是增强和确保 基础和临床研究人员的发展 与研究有关的主要领域的广泛知识 心血管疾病。深入的背景和经验 在培训期间获得的培训旨在使研究员能够 开始作为独立调查人员的职业生涯。有一种明确的 需要有外科观点的调查人员进行这样的研究 作为手术程序和外科病人护理的培训 与研究的进步密切相关。参与的教职员工 来自外科、生理学、内科和 儿科。培训计划将包括研究工作 教职员工单位领导实验室，精选研究生课程， 研究领域的教程、研究研讨会演示文稿和 咨询委员会的定期评价。 该计划包括八个实验室或单位，其中许多 有长期的协作互动。斯特恩博士是 研究血管内皮细胞对低氧血症的适应性反应 巨噬细胞和肿瘤细胞产生的细胞因子 血管特性及因子IX/IXa在血管内皮细胞活化中的作用 体外循环诱导的凝血。斯波尼茨博士是 心脏保存后心功能的研究 将心室力学参数与 伴随着长时间心脏的血管功能障碍 同种异体移植的保存和排斥。哈代博士正在研究 血管激活在同种异体血管形成中的作用 移植。平斯基博士正在研究血管功能障碍 在长时间保存心脏和肺 移植，并专注于潜在的分子 环核苷酸第二信使水平的作用机制 白细胞黏附分子的系统和表达。罗斯医生是 研究细胞的性质和血管反应性 左心室辅助装置的纹理内表面。Dr。 施密特正在检查晚期糖基化引起的血管扰动 最终产物，据信是糖尿病的致病因素 血管病变部分是通过它们与一种新的 血管内皮细胞表达受体。泰尔博士正在研究 胆固醇酯转运蛋白a的结构与功能 高密度脂蛋白代谢的中枢调节因子与胆固醇逆转 运输。塔巴斯博士正在研究泡沫中的胆固醇新陈代谢 细胞发育。 这些项目和单位领导是由一个共同的 关注正常血管壁中的细胞，这些细胞成分 在病理上渗透。情况，如动脉粥样硬化，如 心肌也是如此。受训者将参与的研究项目 参与关注性解剖这些细胞在 血管动态平衡的维持及其参与 骨肉瘤形成和发展的病理事件 血管损伤。我们的目标是吸纳人才和热情 外科实习生，以便引导他们的注意力 从事富有成效和长期的调查工作。

This application requests funds to establish a multidisciplinary postdoctoral training program in mechanisms of cardiovascular disease focussed on drawing surgical trainees into basic laboratory investigation. e rationale for the program is to enhance and insure the development of basic and clinical investigators who have broadly based knowledge in the major fields related to research in cardiovascular disease. The in-depth background and experience obtained during the training period is intended to allow fellows to embark on careers as independent investigators. There is a clear need for investigators with a surgical viewpoint to undertake such training, as operative procedures and care of the surgical patient are closely tied to advances in research. The participating faculty is drawn from the Departments of Surgery, Physiology, Medicine and Pediatrics. The training plan will include research work in the laboratory of a faculty unit leader, selected graduate courses, a tutorial in the research area, research seminar presentations, and periodic evaluations by an Advisory Committee. The program includes eight laboratories or units, many of which have long-standing collaborative interactions. Dr. Stern is studying endothelial adaptive responses to hypoxemia, a novel cytokine produced by macrophages and tumor cells which modulates vascular properties, and the role of Factor IX/IXa in activation of coagulation induced by cardiopulmonary bypass. Dr. Spotnitz is studying ventricular function following cardiac preservation with the goal of relating parameters of ventricular mechanics to vascular dysfunction which accompanies prolonged cardiac preservation and rejection of allografts. Dr. Hardy is studying the role of vascular activation in the setting of allogeneic transplantation. Dr. Pinsky is studying vascular dysfunction following prolonged preservation of the heart and lung for transplantation, and has focussed on underlying molecular mechanisms at the level of cyclic nucleotide second messenger systems and expression of leukocyte adhesion molecules. Dr. Rose is studying the nature and vascular reactivity of cells which populate textured interior surfaces of left ventricular assist devices. Dr. Schmidt is examining vascular perturbation by advanced glycation endproducts, which are believed to contribute to diabetic vasculopathy in part through their interaction with a novel receptor expressed on endothelium. Dr. Tall is studying the structure and function of cholesterol ester transfer protein, a central mediator of HDL metabolism and reverse cholesterol transport. Dr. Tabas is studying cholesterol metabolism in foam cell development. These projects and unit leaders are brought together by a common focus on cells in the normal vessel wall, cellular elements which infiltrate in pathologic. situations, such as atherosclerosis, as well as the myocardium. Research projects in which trainees will participate concern dissection of the roles of these cells in maintenance of vascular homeostasis and their participation in pathologic events underlying the formation and progression of vascular lesions. Our goal is to draw on the talents and enthusiasm of surgical trainees in order to direct their attention to productive and long-term investigative careers.