Regulation of histone methylation by polycomb-like proteins

本项目旨在研究polycomb-like protein如何调控polycomb group （PcG）蛋白并将其招募到靶基因中。在所有多细胞生物的发育过程中，PcG蛋白对于保持数千个基因处于抑制状态至关重要。PcG蛋白在其Polycomb-like蛋白辅助因子的帮助下被招募到它们的靶基因上，这一过程的机制尚不清楚。该项目将确定多梳状蛋白募集和调控PcG蛋白的机制。结果将与多细胞生物的大多数发育过程相关。

This project aims to investigate how polycomb-like proteins regulate polycomb group (PcG) proteins and recruit them to their target genes. During the development of all multicellular organisms, PcG proteins are essential for keeping thousands of genes in a repressed state. PcG proteins are recruited to their target genes with the aid of their Polycomb-like protein cofactors, in a process that is poorly understood mechanistically. This project will determine the mechanism that underpins the recruitment and regulation of PcG proteins by polycomb-like proteins. Outcomes will have relevance for most development processes of multicellular organisms.