Machineries that maintain mitochondrial architecture

该项目旨在定义和表征在不同细胞组织中赋予线粒体特征形状的蛋白质机器。将采用涉及基因编辑和分子细胞生物学定量蛋白质组学的创新方法。该项目期望在蛋白质介导的膜形成和信号传导跨多膜发生的机制方面产生新的知识。项目成果应包括提高澳大利亚基础细胞生物学研究的能力。该项目预计结构生物学的新工具的贡献，有利于治疗和生物技术的应用和培训前沿技术的年轻研究人员。

This project aims to define and characterise the protein machines that give mitochondria their characteristic shape in different cellular tissues. Innovative approaches involving gene editing and quantitative proteomics with molecular cell biology will be employed. This project expects to generate new knowledge in protein-mediated membrane shaping and mechanisms by which signaling occurs across multiple membranes. The project outcomes should include enhanced capacity for fundamental cell biology research in Australia. The project anticipates the contribution of new tools for structural biology, benefiting therapeutic and biotechnology applications and the training of young researchers in frontier technologies.