BEHAVIORAL AND MOLECULAR GENETIC STUDY OF ADHD

描述(改编自申请者摘要)：建议的研究将 利用行为和分子遗传学技术检查病因学 DSM-IV注意力缺陷/多动障碍(ADHD)在100名样本中的分布 选择8-13岁的双胞胎是因为至少有一对双胞胎符合标准 治疗多动症。将利用单变量行为遗传模型来估计 猪瘟亚型病因学的遗传和环境成分 多动症。此外，还将利用双变量行为遗传分析来 直接检验共同基因对提出的三个问题的影响 任何观察到的ADHD精神疾病共病的亚型和病因。 DNA样本将从所有DZ双胞胎及其家人那里获得。 诸如传递不平衡检验等关联分析将被 用来测试ADHD表型的任何成分是否 与理论上看似合理的 候选基因。此外，还对二元区间映射进行了连锁分析 将用于已经为相关的 用来测试先前定位的数量性状基因座是否 6号染色体上的阅读障碍在病因学上也与ADHD有关。

DESCRIPTION (Adapted from Applicant's Abstract): The proposed research will utilize behavioral and molecular genetic techniques to examine the etiology of DSM-IV Attention Deficit/Hyperactivity Disorder (ADHD) in a sample of 100 8-13 year old twins selected because at least one twin meets the criteria for ADHD. Univariate behavioral genetic models will be utilized to estimate the genetic and environmental components of the etiology of the subtypes of ADHD. In addition, bivariate behavior genetic analyses will be utilized to directly examine the influence of common genes on the three proposed subtypes and the etiology of any observed psychiatric comorbidity with ADHD. DNA samples will be obtained from all DZ twins and their families. Association analyses such as the Transmission Disequilibrium Test will be utilized to test whether any component of the ADHD phenotype is significantly associated with any of several theoretically plausible candidate genes. In addition, a bivariate interval mapping linkage analysis will be utilized in a sample of individuals already typed for the relevant markers to test whether a previously mapped quantitative trait locus for reading disability on chromosome 6 is also etiologically related to ADHD.