COMPUTATIONAL ASPECTS OF PRIMATE MEMORY

总体目标是更好地理解记忆 大脑的系统和功能。该项目旨在澄清 大脑皮层神经元网络中暂时性主动记忆的机制 大脑皮层这个问题很重要，因为主动记忆是 对于有效控制顺序行为和更高的 认知功能通常在某些精神疾病中 精神障碍，特别是精神分裂症。这项研究基本上是 计算和有两个密切交织的组成部分：（一） 分析记忆中皮层神经细胞的放电;以及 (b)皮层记忆的计算机模拟模型的发展。的 将研究神经元的反复激活在记忆中的作用 通过对单个细胞和细胞内锋电位的分析， 多个同时录制的单元。前额叶皮层在 记忆将通过研究冷却大脑皮层的影响来检验 对壁细胞和触觉记忆的影响。由此产生的经验 模型将被用来作为来源的实证检验假设， 活跃记忆中的皮质网络动力学

The overall objective is to gain better understanding of the memory systems and functions of the brain. This project is designed to clarify the mechanisms of temporary active memory in neuronal networks of the cerebral cortex. The question is important because active memory is essential for effective control of sequential behaviors and higher cognitive functions which are commonly deranged in certain mental disorders, notably schizophrenia. The proposed research is basically computational and has two closely intertwined components: (a) the analysis of electrical discharge of cortical nerve cells in memory; and (b) the development of computer simulation models of cortical memory. The role of recurrent activation of neurons in memory will be investigated by analysis of the patterns of spike discharge in single units and in multiple simultaneously recorded units. The role of prefrontal cortex in memory will be examined by studying the effects of cooling that cortex on parietal cells and on tactile memory performance. Resulting empirical models will be used as the source of empirically testable hypotheses of cortical network dynamics in active memory.