SURFACE MODIFIED ZIRCONIA IN ANALYTICAL CHROMATOGRAPHY

描述：这项工作的主要目标是开发一个新的类， 基于氧化锆作为载体的分析型HPLC固定相 衬底这些阶段是可能的，因为以前的发展， 多孔、单分散（5 - 10微米）的研究者实验室 氧化锆颗粒具有非凡的化学、机械和热性能， 稳定 氧化锆是一种稳定的基材， pH 0 - 14，在任何色谱上感兴趣的情况下都不会收缩或膨胀 且不会进一步烧结并因此松散 孔体积或结构。本质 目前的建议是开发，表征和应用一套 不同的化学表面改性工艺， 氧化锆的表面化学 调查员的目标是 高选择性和高效的固定相，用于分离 低分子量物质，特别是那些对健康有害的物质 在农业化学品工作场所，包括：杀虫剂，除草剂， 它们的代谢物。感兴趣的表面改性技术将 主要集中在碳包氧化锆的发展， 化学气相沉积，从而利用他相当丰富的经验， 碳涂层材料。研究人员还建议， 类似于硅烷改性的氧化锆的稳定的单体状相 二氧化硅以实现高色谱效率。研究者将 使用Zr（IV）和邻苯二酚之间的金属络合化学， 相关的化合物来做这件事此外，他还将探索 在氧化锆上沉积金属和金属氧化物以改性其表面 化学. 氧化锆载体相对于常规载体的主要技术优势在于： 硅烷化的二氧化硅载体，这使得许多提出的工作成为可能， 是它们在烧结过程中和当在 与洗脱液接触。这使得支撑物可以无损失地使用 固定相的温度远高于100摄氏度，如此高的 温度不仅由于增强的内部和外部温度而提供更窄的峰， 但也将减少有毒物质的净体积 分离过程中产生的有机废物。私家侦探觉得一个 拟议研究中最有趣的方面是 元素碳表面的非凡色谱选择性 在极性和非极性溶质的立体异构体的分离中 在反相条件下。他认为，这种选择性将 具有重要意义的发展非常快速，可靠， 一系列农业化学品危险品的可靠分析方法 物质.

DESCRIPTION: The chief goal of this work is to develop a new class of stationary phases for analytical HPLC based on zirconia as the supporting substrate. These phases are possible due to the prior development in the investigator's laboratory of porous, monodispersed (5-10 micron) particles of zirconia of extraordinary chemical, mechanical, and thermal stability. Zirconia is a stable substrate that resists dissolution from pH 0-14, does not shrink or swell in any chromatographically interesting solvent or ionic strength and does not further sinter and thus loose pore volume or structure upon heating to 800-900 degree C. The essence of the present proposal is to develop, characterize, and apply a suite of different chemical surface modification processes designed to tailor the surface chemistry of zirconia. The investigator's goal is to make highly selective and efficient stationary phases for the separation of low molecular weight species especially those which are health hazards in the agrochemical workplace including: insecticides, herbicides, and their metabolites. The surface modification techniques of interest will focus primarily on the development of a carbon- clad zirconia made by chemical vapor deposition, thus using his considerable prior experience with carbon-coated materials. The investigator also proposes to make stable, monomer-like phases of zirconia analogous to silane-modified silica to achieve high chromatographic efficiency. The investigator will use the metal complexation chemistry between Zr(IV) and catechol and related compounds to do this. Additionally, he will explore the deposition of metals and metal oxides on zirconia to modify its surface chemistry. A major technical advantage of zirconia supports relative to conventional silanized silica supports, that makes much of the proposed work possible, is their very high thermal stability during sintering and when in contact with eluents. This allows the supports to be used without loss of stationary phase at temperatures well above 100 degree C, Such high temperatures not only provide narrower peaks due to enhanced intra- and inter-phase mass transfer but will also decrease the net volume of toxic organic waste produced during the separation. The P.I. feels that one of the most intriguing aspects of the proposed study is the extraordinary chromatographic selectivity of elemental carbon surfaces in the separation of stereo isomers of both polar and nonpolar solutes under reverse-phase conditions. He believes that this selectivity will be of major significance in the development of very fast, reliable and robust analytical methods for a wide array of agrochemical hazardous substances.