PSYCHIATRIC ASSESSMENT OF COGNITION IN THE ELDERLY

此应用程序的目标是使Leuchter博士能够进行 新的研究项目侧重于老年人的认知神经生理学。 Leuchter博士建议在以下方面开发新的技能：1)使用认知 脑激活任务；2)神经生理数据的记录 任务执行过程中的认知变化；3)衰老过程中认知变化的研究。 他已经挑选了一个专家顾问小组，他们将与他合作 培养这些技能。 在这个奖项的支持下，Leuchter博士将利用他的 定量脑电与磁共振成像 (MRI)检查年轻人和老年人认知差异的方法 并研究随着年龄增长而导致的认知功能衰退。他 我将检验以下三个一般假设：1. 青年和老年受试者之间的认知将在 认知伴随的大脑激活和抑制的差异 任务：2.有深部白质损害的老年受试者 与那些没有这些损害的人相比，认知功能障碍的风险更大； 认知任务表现差的老年受试者，他们有 影响大脑系统的白质病变表现不佳 业绩，将面临更大的渐进性或全局性减损风险 而不是那些没有这种损伤的人。Leuchter博士已经开发出增强的qEEG 可能提供更多关于大脑激活的信息的方法 在任务期间比以前可能的更多。他将在这方面使用这些方法 修订研究计划对50名年轻人和100名老年人进行qEEG研究 在执行一系列认知任务时。其中一些 老年受试者会有发生白种人的危险因素 物质损伤。两种定位记录都将使用定量MRI 电极与大脑的关系，并确定大脑的体积 白质病。所有科目都将通过考试 入场时的神经心理测试组合、任务激活的qEEG和磁共振成像 投入到研究中并在三年内。将在以下情况下执行比较 年轻的和年老的受试者，以及老年受试者的分组，以确定 如果任务激活不足与较差的性能和/或 认知能力下降。

The goal of this application is to enable Dr. Leuchter's to undertake a new research program focused on cognitive neurophysiology in the elderly. Dr. Leuchter proposes to develop new skills in : 1) the use of cognitive tasks for cerebral activation; 2) the recording of neurophysiologic data during task performance; and 3) the study of cognitive changes in aging. He has selected a panel of expert consultants who will work with him to develop these skills. With the support of this Award, Dr. Leuchter will utilize his quantitative electroencephalography (QEEG) and magnetic resonance imaging (MRI) methods to examine differences in cognition between young and old adults, and to study the cognitive decline that accompanies aging. He will test the following three general hypotheses: 1. Differences in cognition between young and elderly subjects will be reflected in differences in cerebral activation and inhibition accompanying cognitive tasks: 2. Elderly subjects with deep white-matter lesions are at greater risk for cognitive dysfunction than those without these lesions; and 3. Elderly subjects with poor performance on cognitive tasks, who have white-matter lesions that affect the brain systems showing poor performance, will be at greater risk for progressive or global impairment than those without such lesions. Dr. Leuchter has developed enhanced QEEG methods that may provide more information about cerebral activation during tasks than previously possible. He will use these methods in this revised research plan to study 50 young and 100 elderly adults with QEEG during the performance of a battery of cognitive tasks. Some of the elderly subjects will have risk factors for the development of white- matter lesions. Quantitative MRI will be used both the locate recording electrodes in relation to the brain, and to determine the volume of white-matter disease. All subjects will be examined with a neuropsychological test battery, task-activated QEEG, and MRI at entry into the study and at three years. Comparisons will be performed between young and old subjects, and with groups of elderly subjects, to determine if deficient task activation is associated with poorer performance and/or cognitive decline.