QUANTITATIVE ANALYSIS OF OPTIC DISC/OCULAR HYPERTENSION

本申请描述了一项对眼压升高的辅助研究。 治疗研究(OHTS)，一项由 国家眼科研究所，以确定共焦的效果 扫描激光眼底镜对视盘的客观评价 高眼压患者。 具体目标：1.评价共聚焦扫描激光成像的应用 青光眼视神经损伤和眼部改变的检测技术 高血压患者。2.研究定量时态 视神经地形图与可测视野的关系 损失。3.评价治疗对视神经地形图的影响。4. 比较非裔美国人和白人的视盘地形图参数 高眼压患者。 方法：21个OHTS研究中心中的6个将参加此次活动 辅助研究；至少400名高眼压患者将 包括在内。将使用共聚焦激光扫描眼底镜测量 随机访问时的视盘和乳头周围地形图，以及 此后在研究期间每年一次。共聚焦扫描 加州大学将成立激光检眼镜阅读中心 加州圣地亚哥来处理和分析这些图像。以确保 这项辅助研究将不会危及招募、保留、 实施初步试验或初步调查结果的评估； 阅读中心将对所有人的身份和治疗状态进行屏蔽 病人。将对这些数据进行量化评估，以寻找证据 青光眼的损害和改变，并与其他结构性和 OHTS获得青光眼视神经病变的功能测量。 这项研究将评估眼底成像的这些进展 技术可以提高我们检测和监控的精度 青光眼视神经病变。

This application describes an ancillary study to the Ocular Hypertension Treatment Study (OHTS), a multicenter clinical trial sponsored by the National Eye Institute, to determine the effectiveness of confocal scanning laser ophthalmoscopy to objectively evaluate the optic disc in ocular hypertensive patients. Specific Aims: 1. To evaluate the use of confocal scanning laser imaging techniques to detect glaucomatous optic nerve damage and change in ocular hypertensive patients. 2. To investigate the quantitative temporal relationship between optic nerve topography and measurable visual field loss. 3. To evaluate the effect of treatment on optic nerve topography. 4. To compare topographic optic disc parameters in African-American and white ocular hypertensive patients. Methods: Six of the 21 OHTS study centers will participate in this ancillary study; at least 400 ocular hypertensive patients will be included. Confocal laser scanning ophthalmoscopy will be used to measure optic disc and peripapillary topography at the randomization visit, and annually thereafter for the duration of the study. A Confocal Scanning Laser Ophthalmoscopy Reading Center will be established at University of California, San Diego to process and analyze the images. To ensure that this ancillary study will not jeopardize recruitment, retention, implementation of the primary trial or assessment of the primary findings, the reading center will be masked to identity and treatment status of all patients. These data will be evaluated quantitatively for evidence of glaucomatous damage and change, and compared with other structural and functional measures of glaucomatous optic neuropathy obtained in the OHTS. This study will evaluate whether these advances in fundus imaging technology can improve the precision with which we can detect and monitor glaucomatous optic neuropathy.