DYNAMICS OF OSCILLATORY NEURONAL CIRCUITS

细胞特性和突触特性在神经元动力学中作用的研究 和灵活的振荡神经元回路的操作。 我们利用 甲壳类动物体内的两个中央模式生成回路（CPG） 口胃神经节（STG），在此研究的延续 1969年开始筹备。 口胃系统是最 广泛映射的神经回路。 虽然不 与健康科学直接相关，它允许我们询问基本的 关于振荡电路的设计和功能的问题， 对我们理解运动和感觉回路的影响， 脊椎动物的脊髓和大脑。 1. 突触时程在网络动力学中的作用：一个 评估突触时程对颞叶神经元的作用 幽门和胃CPG的操作，两个口胃回路 其以大约10倍的频率差振荡。 2. 细胞特性和网络动力学的调节： 分析活性膜特性的调节， 单个神经元和对子回路功能的后续影响。 3. 网络动力学和感觉运动加工的调制：A 研究的可塑性，在感觉运动通路所造成的， 调节口胃细胞和突触特性 电机电路 这些问题是通过互动，电生理， 药理学和计算机建模技术。

A study of the role of cellular and synaptic properties in the dynamic and flexible operation of oscillating neuronal circuits. We make use of two central pattern-generating circuits (CPGs) within the crustacean stomatogastric ganglion (STG),in a continuation of studies of this preparation begun in 1969. The stomatogastric system is the most extensively mapped neural circuit presently available. While not immediately related to health sciences, it allows us to ask basic questions about the design and function of oscillatory circuits, with implications for our understanding of motor and sensory circuits in vertebrate spinal cord and brain. 1. The role of synaptic time course in network dynamics: An assessment of the contribution of synaptic time-course to the temporal operation of the pyloric and gastric CPGs, two stomatogastric circuits that oscillate with about a 10 fold difference in frequency. 2. Modulation of cellular properties and network dynamics: An analysis of the modulation of active membrane properties in identified, single neurons and the consequent effects upon sub-circuit function. 3. Modulation of network dynamics and sensorimotor processing: A study of plasticity in sensorimotor pathways resulting from the modulation of cellular and synaptic properties in the stomatogastric motor circuits. These questions are addressed by interactive, electrophysiological, pharmacological and computer modeling techniques.