PSYCHOSTIMULANT EFFECTS: QEEG MEASURES IN ADHD CHILDREN

描述(改编自申请者摘要)：一些研究人员已经 提示注意力缺陷/多动障碍是目前 最常见的儿童精神障碍；估计在3 学龄儿童和学龄儿童分别为50%和75% 为转诊的儿童准备的。虽然目前还没有治愈的方法， 心理刺激治疗改善70-80岁人群的行为症状 ADHD儿童的百分比，取决于反应的定义。 尽管哌醋甲酯(MPH)是使用最广泛的中枢神经系统 精神刺激剂，是MPH实现其功能的神经机制 影响在很大程度上是未知的。我们相信，这会导致 可通过qEEG度量来测量的皮质唤醒。本研究 建议研究精神刺激对脑电活动的影响 多动症儿童在认知激活过程中。QEEG数据将 然后接受Leuchter开发的算法，并与 估计电极部位下的脑灌注量。最后， 测量大脑活动和改善生活质量之间的关系 我们将考察他们的认知表现。

DESCRIPTION (Adapted from Applicant's Abstract): Some researchers have suggested that Attention-Deficit/Hyperactivity Disorder is currently the most prevalent childhood psychiatric disorder; estimates range between 3 percent and 5 percent for school-age children and 50 percent to 75 percent for clinic-referred children. While there is not yet a cure, psychostimulant treatments ameliorate behavioral symptomatology in 70-80 percent of children with ADHD, depending on how response is defined. Although Methylphenidate (MPH) is the most widely used of the CNS psychostimulants, the neural mechanism through which MPH achieves its effects are largely unknown. We believe that it results in increased cortical arousal that may be measured by the QEEG metric. This study proposes to examine the psychostimulant effects on brain electrical activity among children with ADHD during cognitive activation. The QEEG data will then be subjected to an algorithm developed by Leuchter and associates to estimate the cerebral perfusion underlying the electrode sites. Finally, the relationship between measures of brain activity and improvements in cognitive performance will be examined.