APPROACHES TO CHIRAL CARBON AND NITROGEN COMPOUNDS

描述：主要研究者指出，该计划 继续评价手性、非外消旋 双环内酰胺。他指出，内酰胺，来自 光学活性氨基醇（通过还原氨基酸）和3-或 4-酮基羧酸提供了手性模板， 不寻常的合成反应：烷基化，加成， 环加成（光、热、酸催化），还原，氧化， 等人他进一步指出，这些化学品的产品 反应导致过多的对映体纯的季碳 化合物，其中许多是具有重要生物活性的天然产物， 活动值得注意的是，本提案将扩大这些 研究连续手性中心，手性吡咯烷和 哌啶。后者被认为是一个重要的核心系统， 生物活性化合物的数量。

DESCRIPTION: The principal investigator states that the program to continue to evaluate the synthetic properties of chiral, non-racemic bicyclic lactams is presented. He notes that the lactams, derived from optically active amino alcohols (by reduction of amino acids) and 3- or 4-ketocarboxylic acids provide a chiral template upon which to perform an unusual number of synthetic reactions: alkylations, additions, cycloadditions (photo, thermal, acid-catalyzed), reductions, oxidations, and others. He further indicates that the products of these chemical reactions lead to a plethora of enantiomerically pure quaternary carbon compounds, many of which are natural products with important biological activity. It is noted that the present proposal will extend these studies to contiguous chiral centers, chiral pyrrolidines and piperidines. The latter are said to be important core systems in a number of biologically active compounds.