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AMBISOME VS AMPHOTERICIN B AND FLUCONAZOLE IN CRYPTOCOCCAL MENINGITIS IN AIDS

AMBISOME VS AMPHOTERICIN B AND FLUCONAZOLE IN CRYPTOCOCCAL MENINGITIS IN AIDS
Ambisome 对比两性霉素 B 和氟康唑治疗艾滋病隐球菌性脑膜炎
批准号：
6281667
负责人：
PHILIP C JOHNSON
金额：
$1.36万
依托单位：
UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1998-11-30
来源：
https://reporter.nih.gov/project-details/6281667
关键词：
AIDS AIDS therapy Cryptococcus amphotericin B bacterial meningitis clinical research combination chemotherapy drug screening /evaluation fluconazole human subject human therapy evaluation microorganism disease chemotherapy opportunistic infections

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中文摘要
翻译
这是一项第三阶段的随机、双盲、多中心研究 评价两种剂量AmBisome的安全性、耐受性和有效性 (脂质体两性霉素B)与两性霉素B，其次是氟康唑， 首次发生急性隐球菌性脑膜炎的患者 艾滋病。患者将接受AmBisome或两性霉素B静脉注射，为期2周， 然后是8周的氟康唑。主要的疗效结果是 治疗成功的发生率在可评价的 子群。
英文摘要
This is a Phase III randomized, double-blind, multicenter study designed to evaluate the safety, tolerability and efficacy of two doses of AmBisome (Liposomal amphotericin B) versus amphotericin B, followed by fluconazole, for a first episode of acute cryptococcal meningitis in patients with AIDS. The patient will receive AmBisome or amphotericin B IV for 2 weeks, followed by eight weeks of fluconazole. The primary efficacy outcome is the incidence rate of the therapeutic success assessed in the evaluable subgroup.
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会议论文
COMPARISON OF ANTIRETROVIRAL ACTIVITY OF 3 COMBINATION REGIMENS IN HIV+ PATIENTS
AMBISOME COMPARED WITH AMPHOTERICIN B FOR HISTOPLASMOSIS IN AIDS PTS
COMPARISON OF ANTIRETROVIRAL ACTIVITY OF 3 COMBINATION REGIMENS IN HIV+ PATIENTS
AMBISOME VS AMPHOTERICIN B AND FLUCONAZOLE IN CRYPTOCOCCAL MENINGITIS IN AIDS
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