SENSITIVE IMMUNOASSAY FOR HIV-1 P24 IN MOTHER'S MILK

描述：(改编自提案摘要)BIOTRACES Inc. 开发了一种用于同位素的新型多光子探测系统(MPDTM)，该系统 比标准检测系统灵敏一千倍。MPD 增强免疫分析是一种适合于研究和临床的新技术。 针对生物分子的最高灵敏度定量进行了优化的设施。 拟议研究的目标是利用这项新技术来 建立一种快速、可靠、定量检测HIV-1p24抗原的方法 存在于母乳中。与目前“最先进”的ELISA相比 MPD增强型免疫分析的灵敏度大约提高了1000倍。 对每毫升血清中约10至50个病毒粒子水平的定量是 预期中。更具体地说，这种p24抗原的新检测方法将用于 HIV-1母婴传播的研究。 建议的商业应用：不可用

DESCRIPTION: (Adapted from the proposal's abstract) BIOTRACES Inc. has developed a novel Multiple Photon DetectionTM (MPDTM) system for isotopes which is a thousand times more sensitive than standard detection systems. The MPD enhanced immunoassay is a new technique appropriate for research and clinical facilities optimized for the highest sensitivity quantitation of biomolecules. The objective of the proposed research is to utilize this new technology to develop a fast, reliable and quantitative immunoassay for HIV-1 p24 antigen present in mother's milk. When compared with current "state of the art" ELISAs the MPD enhanced immunoassay permits about a 1,000 fold greater sensitivity. Quantitation on the level of about ten to fifty virions per ml of serum is expected. More specifically, this new assay for p24 antigen will be used in studies of the transmission of HIV-1 from mother to child. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE