OXYGEN INDEPENDENT INTERFERENCE FREE GLUCOSE SENSORS

拟议的研究提供了一种创新的方法， 在体内葡萄糖监测中遇到的严重错误 无氧干扰的合理设计 氟碳/金属化碳酶电极。 使用 全氟化合物，由于其 显著的氧溶解性，作为生物复合材料的主要成分 电极，应满足内部的氧气需求。 新 电极的催化金属-碳组分将提供 优先检测酶促释放的过氧化物物质， 并且不受常见的电活性干扰。 所得 因此，碳氟化合物/金属化碳生物复合微电极将 具有触发适当警报所必需的高精度，以及 做出有效的治疗决定

The proposed research offers an innovative approach for addressing serious errors encountered in in-vivo glucose monitoring through the rational design of oxygen-independent interference-free fluorocarbon/metalized-carbon enzyme electrodes. The use of perfluorochemicals, often employed as blood substitutes due to their remarkable oxygen solubility, as a major component of the biocomposite electrode, should satisfy the oxygen demand internally. The new catalytic metal-carbon component of the electrode would offer preferential detection of the enzymatically-liberated peroxide species, and freedom from common electroactive interferences. The resulting fluorocarbon/metalized-carbon biocomposite microelectrode will thus possess the high accuracy essential for triggering proper alarms, and for making valid therapeutic decisions.