ECHO/TRANSMISSION ULTRASOUND COMPRESSION PLATE SCANNER

乳腺癌的早期诊断和治疗可以提高生存率。 我们提案的一个独特之处是， 可以在相同的扫描机器中获得超声模态 各个图像可以被配准、融合和组合。 我们将 在构建的实验室上演示以下成像模式 扫描仪：1）2-D折射投影; 2）2-D吸收投影3） 2-D和3-D反射率; 4）2-D和3-D逆散射;以及5）2-D 和三维散射数密度。 我们将展示改进的 通过相位像差校正获得的空间分辨率， 孔径采用8 × 8单元，1.5维，波带片阵列结合 这个实验室扫描仪。在第二阶段，我们将增加 将1.5维阵列扩展到1,000多个元素， 多个切片（从横向阵列移动获得）的整个 乳房 在第三阶段，扫描仪可能会升级， X射线乳房摄影和超声波图像，可以配准， 使用最新的可视化技术进行组合和融合。就地 图像引导的穿刺活检特别适合于以后的模型。 拟议的商业应用： 这项研究可用于乳腺癌的检测、诊断和治疗。 筛选所采取的方法将允许超声成像，X射线 乳腺X线摄影和针吸活检技术将在未来结合起来 扫描仪逆散射和相位畸变校正 算法将应用于其它超声成像领域， 在环境成像中。

Early diagnosis and treatment of breast cancer increases survival rates. A unique feature of our proposal is that reflection and transmission ultrasound modalities can be obtained in the same scanning machine and the respective images can be registered, fused and combined. We will demonstrate the following imaging modalities on a constructed laboratory scanner: l) 2-D refraction projection; 2) 2-D absorption projection 3) 2-D and 3-D reflectivity; 4) 2-D and 3-D inverse scattering; and 5) 2-D and 3-D scattering number density. We will demonstrate the improved spatial resolution obtained with phase aberration correction and larger apertures using an 8 by 8 element, 1.5-D, zone plate array incorporated into this laboratory scanner. In phase II, we will increase the size of the l.5-D array to over 1,000 elements to electronically scan one slice of multiple slices (obtained from lateral array movement) of the entire breast. In phase III, the scanner may be upgraded to provide sequential X-ray mammographic and ultrasound images, which could be registered, combined and fused using the latest visualization technology. In-place image-guided needle biopsy is particularly suited to later models. PROPOSED COMMERCIAL APPLICATIONS: This research has application to breast cancer detection, diagnosis and screening. The approach taken will allow ultrasound imaging,x-ray mammography and needle biopsy technologies to be combined in future scanners. The inverse scattering and phase aberration correction algorithms will have application in other ultrasound imaging areas and in environmental imaging.