TEXAS CANCER GENETICS CONSORTIUM

描述：(应聘者描述)我们建议进行德克萨斯州癌症遗传学研究 对癌症遗传网络(CGN)RFA的回应 CA-97-004。TCGC将为中广核带来BASIC方面的广泛专业知识 和临床癌症遗传学、人类和分子遗传学、 机密的人类癌症遗传学数据，人类社区推广 遗传学、专业和公共教育，以及对老年人的心理社会研究 癌症遗传咨询和检测的影响。TCGC将包括 现有癌症高危临床人群，德系犹太人 人群、家族乳房、结肠癌、MEN2、NF1和其他 遗传易感性综合征，其中许多在几十年的研究中被跟踪， 癌症高危患者参与筛查和早期发现 研究或化学预防试验，以及癌症患者的大型数据库 从中找出可能被招募的高危家庭成员 中广核。德克萨斯州的人口在种族构成上是多样化的，TCGC 包括具有经过证明的跟踪记录的调查人员，以评估 拉美裔和非裔美国人社区在医疗保健方面，在提供 对这些社区及其医疗保健提供者进行健康教育，并在 招募他们参加家族性癌症登记和临床 和研究研究。这项申请的资金将提供 我们的TCGC有机会加强我们在财团内部的互动， 将我们的研究经验和专业知识贡献给中广核的设计和 实施，并利用我们在招聘方面的经验和专业知识 高危患者的CGN方案。我们的长期目标是做出贡献 对于癌症易感基因的鉴定，其作用机制 行为、频率、外显性和遗传或环境风险修饰物， 将这些信息集成到最佳的患者管理中，并评估 需要并提供教育，以解决伦理和心理社会关切 围绕着人类癌症遗传学。

DESCRIPTION: (Applicant's Description) We propose a Texas Cancer Genetics Consortium (TCGC) in response to the Cancer Genetics Network (CGN) RFA CA-97-004. This TCGC would bring to the CGN extensive expertise in basic and clinical cancer genetics, human and molecular genetics, management of confidential human cancer genetics data, community outreach in human genetics, professional and public education, and psychosocial studies of the impact of cancer genetic counseling and testing. The TCGC will include existing cancer high risk clinical populations, Ashkenazi Jewish populations, registries of familial breast, colon, MEN2, NF1 and other genetic susceptibility syndromes, many followed in studies for decades, patients at high cancer risk participating in screening and early detection studies or chemoprevention trials, and a large database of cancer patients from which to identify high risk family members for potential recruitment to the CGN. The Texas population is diverse in ethnic makeup, and the TCGC includes investigators with proven track records in assessing needs of the Hispanic and African American communities in health care, in providing health education to those communities and their healthcare providers, and in recruiting their participation in familial cancer registries and clinical and research studies. Funding of this application would provide the opportunity for our TCGC to strengthen our within consortium interactions, to contribute our research experience and expertise to the CGN design and implementation, and to utilize our experience and expertise in recruitment of high risk patients to CGN protocols. The long term goal is to contribute to the identification of cancer susceptibility genes, their mechanisms of action, frequency, penetrance, and genetic or environmental risk modifiers, to integrate this information into optimal patient management, and to assess needs and provide education to address the ethical and psychosocial concerns surrounding human cancer genetics.