SPF ANIMAL BREEDING AND RESEARCH PROGRAM

描述(改编自申请人的摘要)：申请人提出 延续大规模、财政独立的生产资源 可用于艾滋病相关研究的SPF恒河猴。1988年， 286只健康的传统恒河猴致力于一个派生 旨在建立SPF殖民地的策略。截至1995年12月31日， 这个群体已经进化成533只健康、多产、社交丰富的恒河猴 猴子致力于满足远程、全国性的研究和测试 需要。申请人目前的SPF成就包括九年的 阳性和不确定试验的持续病毒筛查和剔除 动物。菌落的很大一部分也达到了长程SPF 有SPF父母的所有育种者的标准(目前为73%)，并且没有生命 与病毒阳性伴侣一起居住的时间历史(目前 58%)。申请人的设施和管理策略确保关闭 满足以下条件的环境中SPF恒河猴的群体保护 当前社会对动物福利的期望。繁育统计数据 过去的八年和SPF动物的销售在 申请。申请者计划能够生产大约 每年100-200只SPF恒河猴用于下一年的研究 获奖期。在下一次颁奖期间，调查人员可以选择SPF 恒河猴按血缘系数增加免疫同质性， 并且还可以具有先前建立的单个细胞系伴随 这只动物。遗传转包与行为免疫伴侣 研究拨款与SPF恒河猴质量保证直接相关， 殖民地管理、生产力和福祉。在蜂群中繁殖 无需中断资源即可支持调查人员 遗传学、行为学和免疫学的领域。

DESCRIPTION (Adapted from the applicant's abstract): The applicants propose continuation of a large-scale, financially independent production resource of SPF rhesus monkeys that can be used in AIDS-related research. In 1988, 286 healthy conventional rhesus monkeys were dedicated to a derivation strategy designed to establish the SPF colony. As of December 31, 1995, this colony has evolved to 533 healthy, productive, socially-enriched rhesus monkeys dedicated to meeting long range, national research and testing needs. The applicant's current SPF achievements include nine years of sustained viral screening and culling of positive and indeterminate test animals. A significant portion of the colony also meets the long range SPF criteria of all breeders having SPF parents (currently 73%), and no life time history of being housed with a virus positive companion (currently 58%). The applicant's facilities and management strategies assure closed colony protection for SPF rhesus monkeys in an environment that meets current societal expectations for animal welfare. Breeding statistics for the past eight years and sales of SPF animals are discussed in the application. The applicants project being able to produce approximately 100-200 SPF rhesus monkeys per year for investigative use during the next award period. During the next award period, investigators can select SPF rhesus monkeys by kinship coefficient to increase immunological homogeneity, and can also have a previously established individual cell line accompany the animal. The genetic subcontract and behavioral immunology companion research grant have direct relevance to SPF rhesus monkey quality assurance, colony management, productivity, and well-being. Breeding in the colony does not have to be disrupted for the resource to support investigators in the fields of genetics, behavior, and immunology.