MECHANISM OF ACTION OF GROWTH HORMONE

描述(改编自申请人的摘要)：在啮齿动物那里 是来自同一基因的两种生长激素受体亚型。《长河》 Form GHRL跨越细胞膜，可以向大多数(如果不是全部) 生长激素可能通过激活胞浆蛋白酪氨酸发挥作用 激酶、JAK2。受体的短亚型GHR仅由 胞外区和亲水性尾巴，但不知何故被拴在 参与激素结合的细胞表面，可能 发信号。古德曼博士将研究钙离子内流的影响 由生长激素引起的上述影响的表达，特别是 难治性反应。钙离子的作用及其潜在的第二性 信使充当信令级联的调制器或导向器 将探索由酪氨酸引发的细胞蛋白质的磷酸化。

DESCRIPTION (Adapted from the applicant's abstract): In the rodent there are two isoforms of the GH receptor derived from the same gene. The long form GHRL spans the cell membrane and can signal most if not all of the effects of GH probably through activation of the cytosolic protein tyrosine kinase, JAK2. The short isoform of the receptor, GHRs consists only of the extracellular domain and a hydrophilic tail, but is somehow tethered to the cell surface where it participates in hormone binding and probably signaling. Dr. Goodman will examine the effects of the influx of ca2+ brought on by GH on the expression of the above effects and in particular the refractory response. The role of Ca2+ and its potential second messenger function as a modulator or director of the signaling cascades initiated by tyrosine phosphorylation of cellular proteins will be explored.