MAGNETIC RESONANCE SPECTROSCOPIC NEOPLASM IMAGING

该项目的总体目标是开发质子磁共振光谱成像（MRSI）技术及其后续应用，以帮助肿瘤患者的诊断和治疗监测。 作为一种非侵入性的工具，提供独特的生化信息补充传统的成像，在体内MRSI已被证明有一个有价值的作用，在癌症的研究。 然而，显着的技术改进，特别是可靠的采集体积MRSI数据的肿瘤在整个身体，需要充分实现这种强大的成像模式的临床潜力。该提案的重点是继续技术开发创新的光谱技术，以强大和有效的收集，量化和显示这一信息。 该技术将在幻影，正常志愿者，以及脑肿瘤，鳞状细胞癌和乳腺癌的转移性颈淋巴结患者进行测试。 在持续的技术发展的同时，我们将进行一项集中的、对照良好的临床研究，比较质子MRSI和FDG PET区分放射性坏死和复发性胶质瘤的能力。

The overall goal of this project is the development of proton magnetic resonance spectroscopic imaging (MRSI) techniques and their subsequent application for aiding in the diagnosis and treatment monitoring of patients with tumors. As a noninvasive tool providing unique biochemical information supplemental to conventional imaging, in vivo MRSI has been shown to have a valuable role in the study of cancer. However, significant technical improvements, particularly for the reliable acquisition of volumetric MRSI data from tumors throughout the body, are needed to fully realize the clinical potential of this powerful imaging modality. This proposal is focused on the continued technical development of innovative spectroscopic techniques for the robust and efficient collection, quantification, and display of this information. The techniques will be tested on phantoms, normal volunteers, as well as patients with brain tumors, metastatic neck nodes of squamous cell carcinomas, and breast cancer. In parallel with the continued technical development, we will conduct a focused, well-controlled clinical study comparing the abilities of proton MRSI and FDG PET for differentiating radiation necrosis from recurrent glial tumors.