FEEDING STRATEGIES FOR LOW BIRTH WEIGHT INFANTS

虽然使用强化母乳（FMM，母亲自己的牛奶加上 补充蛋白质，矿物质和维生素），用于喂养早产儿 婴儿越来越多，这对母亲来说是一个艰难的过程， 变得昂贵。 然而，由于发病率低，住院时间短， 成本变得不那么重要。 这项研究的主要假设是， FMM可保护早产儿免受迟发性脓毒症和/或NEC， 与喂养相比， 早产儿配方奶粉，因为它提供了特异性功能抗体， 新生儿环境中常见的病原体。 次要假设[原文] 将被测试的是：1）健康状况改善，但增长放缓的tof FMM喂养的早产儿与配方奶粉喂养的早产儿相比， （2）产奶量不足， 母亲的压力，这可以减少常见的托儿所的做法， 母婴之间的皮肤接触 小于30周的早产儿（n = 272）将完成以下研究： 具体目的如下：1）确定脓毒症的发病率 和/或NEC和住院时间， 喂养早产儿FMM， 巴氏灭菌的供体人乳或早产儿配方奶粉，并在非随机 FMM与早产儿配方奶粉的比较; 2）确定FMM与早产儿配方奶粉的关系 在系列牛奶样品中的特异性功能性抗体滴度之间， 病原体特异性脓毒症（表皮葡萄球菌， 金黄色葡萄球菌），并确定是否有特定的保育方案， 例如母婴之间的皮肤接触， 在血清和乳汁中开发功能性抗体; 30确定 FMM的长期后遗症（生长、身体组成、健康）与 早产儿配方奶粉喂养，以及4）确定 早产儿母亲应激与产奶量的关系 婴儿，和4）确定皮肤的影响之间的关系- 皮肤收缩作为一种减压方法。

Although the use of fortified mother's milk (FMM, mother's own milk plus supplemental protein, minerals, and vitamins) for feeding premature infants is increasing, it is a difficult process for the mothers and may become costly. However, with less morbidity and shorter hospitalization cost becomes less relevant. The primary hypothesis of this study is that FMM protects the premature infant from late-onset sepsis and/or NEC and shortens the duration of hospitalization compared with the feeding of preterm formula because it provides specific functional antibody against common pathogens in the neonatal environment. Secondary hypothesis [sic] that will be tested are: 1) The improved health but slower growth tof the FMM fed compared with the formula-fed premature infant continues beyond hospitalization; and 2) Insufficient milk production is related to maternal stress which can be reduced by the common nursery practice of skin-to-skin contract between mother and infant. Premature infants less than 30 weeks (n = 272) will complete a study of the following specific aims: 1) To determine the incidence of sepsis and/or NEC and duration of hospitalization in both a randomized trial of feeding premature infants FMM supplemented either with fortified pasteurized donor human milk or preterm formula and in a non-randomized comparison of FMM and preterm formula; 2) To determine the relationship between specific functional antibody titers in serial milk samples the incidence of pathogen--specific sepsis (Staphylococcus epidermidis, Staphylococcus aureus), and to determine if specific nursery protocols, such as skin-to--skin contact between mother and infant affect the development of functional antibody in serum and milk; 30 To determine long-term sequelae (growth, body composition, health) of FMM versus formula feeding in premature infants, and 4) To determine the relationship between stress and milk production in mothers of premature infants, and 4) To determine the relationship between the effect of skin- to-skin contract as a stress reduction method.