SPATIAL ORIENTATION OF MARINE MOLLUSK CLIONE LIMACINA

拟议工作的总体目标是利用CLONE作为模型 研究动物行为的神经基础的学科。具体的 目的是研究确定的空间定向的神经机制。 通过他汀囊受体的活性。这项提议旨在 继续就负责改革的中央机制开展正在进行的工作 在不同行为背景下的状态囊信息处理中， 其中之一涉及触发正常反应的逆转，以及 其中两个被认为是暂时降低了 在食物获取和被动回避过程中的他汀囊输入 行为。 他汀囊细胞已经被鉴定出来，它们的活动在不同的时间 倾斜度通过一个非常巧妙的记录系统被记录下来。 此外，接受他汀囊输入的中枢神经元 提供能够修改游泳活动的输出，已经被 找到了。失踪的拼图碎片是一个完整的身份证明 详细描述了产生尾部弯曲和尾部弯曲的尾部运动神经元 从而改变游泳的方向。这是我们的第一个目标 对尾部运动神经元的详细描述。一次 确认，调查人员建议描述细胞和 游泳和屈尾改变的突触机制 在不同的行为中的活动。他们选择了三种行为 可以很容易地在实验中模拟的环境。来自…的逆转 通过简单的更改可以触发正向到负向趋地性 记录系统中的温度。明显的抑制作用 摄食行为期间的他汀囊输入将通过简单的 启动喂食活动-喂食过程中涉及的回路很好 调查人员所知道的。最后，触发被动的刺激 回避行为可以在较少的准备工作中提供，以 描述转向过程中与行为相关的活动变化 系统。 总体而言，研究人员建议描述行为 网络环境下空间定位系统的可塑性 行为相关语境中的调制。

The overall object of the proposed work is to utilize Clione as a model subject for studying the neural basis of animal behavior. The specific aim is to study neural mechanisms of spatial orientation as determined by the activity of statocyst receptors. The proposal is designed to continue ongoing work on the central mechanisms responsible for changes in statocyst information processing in different behavioral contexts, one of which involves triggering a reversal in the normal response, and two of which are believed to temporarily decrease the significance of statocyst inputs during food acquisition and during passive avoidance behavior. Statocyst cells have been identified, and their activity during varying degrees of tilt has been documented with a very clever recording system. Furthermore, central neurons which receive statocyst input, and which provide output that is capable of modifying swimming activity, have been found. The missing puzzle piece is a complete identification and thorough description of tail motoneurons which produce tail bending and thus alter the direction of swimming. This represents the first goal of the project - a thorough description of tail motoneurons. Once identified, the investigators propose to describe the cellular and synaptic mechanisms of modification of swimming and tail bending activities during different behaviors. They have chosen three behavior contexts which can be easily simulated experimentally. A reversal from positive to negative geotaxis can be triggered by simply changing temperature in the recording system. The apparent inhibition of statocyst inputs during feeding behavior will be studying by simply initiating feeding activity - the circuits involved in feeding are well known to the investigators. Finally, stimuli that trigger passive avoidance behavior can be delivered in a reduced preparation, to describe behaviorally relevant changes in activity in the steering system. Overall, the investigators propose to describe behavioral plasticity in the spatial orientation system following network modulation in behaviorally relevant contexts.