ANIMAL MODELS OF HUMAN VIRAL INFECTIONS

本研究的目的是利用流感的动物模型 病毒感染，它有几个特征类似于人类疾病， 用于评价候选抗病毒剂的临床前潜力。 动物模型由实验室小鼠的感染组成， 已成功用于评价流感病毒抑制化合物 和生物反应调节剂（BRM）， 动物模型合同。 该模型采用了几个参数， 衡量疾病的严重程度。包括使用脉搏血氧仪 目前广泛用于临床监测每日血氧 饱和度 整个研究计划利用了病毒学 这种病毒的专业知识，化学治疗的专业知识，和免疫学 背景非常适合完成所需的工作。

The objective of this research is to utilize an animal model of influenza virus infection, which has several features similar to the human disease, for evaluating the preclinical potential of candidate antiviral agents. The animal model consists of an infection of laboratory mice which have been used successfully for evaluating influenza virus-inhibitory compounds and biological response modifiers (BRMs) in the now-terminating NIAID Animal Models contract. This model employs several parameters for measuring disease severity. including utilization of pulse oximetry currently widely used in the clinic for monitoring daily blood oxygen saturation. The overall research plan utilizes a blend of virologic expertise with this virus, chemotherapeutic expertise, and immunologic backgrounds well suited to achieve the work required.