MINORITY PREDOCTORAL FELLOWSHIP PROGRAM--NIGMS

尽管过去一年结核病(TB)控制再次受到关注 十年来，正在进行的结核病治疗计划没有根据影响进行评估 他们可能会对当地或全球的结核病流行病学产生影响。 目前，昂贵且难以治疗的多种药物的出现- 结核分枝杆菌耐药株威胁到最近在结核病方面的进展 控制力。这个博士论文项目是为了回应 目前关于持续结核病可能影响的知识存在差距 控制战略，以及潜在的流行病和经济 替代战略的好处。数据收集过程将 由对3,000名穷人进行的家庭调查组成 秘鲁利马北部的一个社区。该调查数据将用于 估计病毒的大小和平均传染性持续时间 几组不同的结核病病例，包括那些 耐多药结核病。这些数据将与数学计算相结合 结核病传播动态的模型，以便比较正在进行的 和替代的当地结核病治疗和控制战略，以及 告知全球结核病控制政策的目的。数据收集， 分析，并撰写博士论文研究项目将是 于1999年6月前完成。

Despite renewed attention to tuberculosis (TB) control in the last decade, ongoing TB treatment programs are not evaluated by the impact they may be having on the local or global epidemiology of TB. Currently, the emergence of costly- and difficult-to-treat multidrug- resistant strains of M. tuberculosis threatens recent gains in TB control. This doctoral thesis project has been designed to respond to gaps in current knowledge regarding the likely impact of ongoing TB control strategies, and the potential epidemiological and economic benefits of alternative strategies. The data collection process will consist of a household survey of 3,000 individuals conducted in a poor community of northern Lima, Peru. This survey data will be used to estimate the size, and the average duration of infectiousness, of several different groups of TB cases, including those who have multidrug-resistant TB. This data will be coupled with mathematical models of the transmission dynamics of TB, in order to compare ongoing and alternative local TB treatment and control strategies, with the purpose of informing global TB control policy. The data collection, analysis, and writing for the doctoral thesis research project will be completed by June 1999.