EVALUATION OF TUNED APERTURE CT FOR 3-D MAMMOGRAPHY

描述(改编自申请者摘要)：主要目的 应用是一种实用、高分辨率、 体外三维(3-D)乳房X线摄影系统。这个过程 利用一种名为调谐孔径的新的断层合成重建方案 计算机断层扫描(TACT)。该方法是基于光学的扩展 光圈理论将传统的透射式射线照相与 计算机断层扫描。它与其他层析成像有根本的不同。 方法所需的所有投影信息 3-D重建是从二维(2-D)投影导出的，其 在曝光时，投影几何形状未知。这种差异 促进高分辨率3-D成像仪的生产 使用从现有技术派生的相对简单的技术 乳房X光检查单位。该研究计划涉及重新配置一种常规的 基于现有数字探测器的固态乳房X光摄影系统 模拟机智，进行综合分析，使用专门开发的 测试对象，将3-D成像性能与理论成像性能进行比较 预测，并使用结果信息作为模拟的指南 体外临床表现。通过这些模拟，Tact将被 临床与常规钼靶X线影像诊断的比较 可从特别挑选和准备的身体上获得的表演 使用ROC分析的样本用于病变检测任务和适当的 病变定位任务的参数分析。

DESCRIPTION (Adapted from Applicant's Abstract): The main objective of the application is simulation and testing of a practical, high-resolution, three-dimensional (3-D) mammographic x-ray system in vitro. The process makes use of a new tomosynthetic reconstruction scheme called tuned-aperture computed tomography (TACT). This method is based on an extension of optical aperture theory that links conventional transmission radiography with computed tomography. It differs fundamentally from other tomographic methods by virtue of that fact that all projection information required for 3-D reconstruction is derived from two-dimensional (2-D) projections whose projection geometry is unknown at the time of exposure. This difference facilitates the production of high-resolution 3-D imager over extended periods of time using relatively simple technology derived from existing mammography units. The research plan involves reconfiguring a conventional solid-state mammography system based on an existing digital detector to simulate TACT, undertaking comprehensive analyses using specially-developed test objects to compare imaging performance in 3-D with theoretical predictions, and using resulting information as a guide for simulating clinical performance in vitro. Through these simulations TACT is to be compared clinically with conventional mammographic images for diagnostic performance obtainable from specially selected and prepared cadaveric specimens using ROC analysis for lesion-detection tasks and appropriate parametric analyses for lesion-location tasks.