MICROVASCULAR INJURY DURING EXTRACORPOREAL LIFE SUPPORT

这是这位候选人在德克萨斯大学休斯顿分校担任助理教授后的第一个教职。作为NRSA研究员，他学习了基本的研究技术，这是德克萨斯大学医学部NIGMS创伤和烧伤研究培训基金的一部分。这导致发表了与肺损伤相关的微血管通透性的手稿，并在创伤和烧伤中使用了体外生命支持(ECLS)技术。在他执教的第一年，他在德克萨斯大学休斯顿分校的淋巴和微血管研究中心开发了独立和合作的项目。他是ECLS项目的联席主任，也是德克萨斯大学休斯顿分校儿科创伤项目的主任。拟议的项目是候选人之前研究经验的自然延伸，与他在创伤和ECLS领域的临床专业知识直接相关。临床科学家和生物工程师之间的这种拟议关系将使生产性转化研究具有最大潜力。本项目的重点是器官功能障碍程度和微血管通透性改变与中性粒细胞/内皮细胞激活和相互作用程度的相关性。初步工作包括用ECLS建立犬微血管通透性增加的模型。德克萨斯大学健康科学中心、德克萨斯医学中心和莱斯大学为年轻研究人员提供了独特的科学环境。候选人的赞助商特别适合这个项目的成功。艾伦博士在体外循环期间微血管屏障损伤方面的专业知识是该项目的核心。麦金泰尔博士在PMN/内皮/血流相互作用方面的专业知识将为候选人的培训提供重要的补充。

This is the candidate's first faculty position as Assistant Professor at the University of Texas-Houston. He learned basic research techniques as an NRSA Fellow, as part of a NIGMS training grant in trauma and burn research at the University of Texas Medical Branch. This resulted in the publication of manuscripts on microvascular permeability associated with lung injury and the use of extracorporeal life support (ECLS) techniques in trauma and burns. In his first year on faculty, he has developed both independent and collaborative projects at the Center for Lymphatic and Microvascular Studies at the University of Texas-Houston. He is co-director of the ECLS program and director of the Pediatric Trauma program at the University of Texas-Houston. The proposed project is a natural extension of the candidate's previous research experience and is directly related to his clinical expertise in the areas of trauma and ECLS. This proposed relationship between clinical scientist and bioengineers will allow the greatest potential for productive translational research. The focus of this project is the correlation of the degree of organ dysfunction and alterations in microvascular permeability with the degree of PMN/endothelial activation and interactions. Preliminary work has included the development of a canine model of increased microvascular permeability with ECLS. The University of Texas Health Science Center, Texas Medical Center and Rice University provide a unique scientific environment for young investigators. The candidate's sponsors are especially suited for the success of this project. Dr. Allen's expertise in microvascular barrier injury during cardiopulmonary bypass is central to the project. Dr. McIntire's expertise in PMN/endothelial/blood flow interactions will provide an important addition to the candidate's training.