METHAMPHETAMINE ABUSE PHARMACOTHERAPY IN AIDS PATIENTS

描述：(申请人摘要) 滥用甲基苯丙胺与性行为有关的现象现在很普遍 在同性恋者和双性恋者中。 我们建议对两种有希望的推定药物的疗效进行调查 兴奋剂滥用药物治疗，如地昔帕明和舍曲林，作为戒断 甲基苯丙胺(MAMPH)依赖的易化治疗 患有有症状的艾滋病的同性恋和双性恋男性。这个 药物治疗将作为辅助治疗应用于与 艾滋病医疗保健诊所。 这项研究将采用安慰剂对照、双盲、随机 作业，三个单元平行分组设计，将评估120名受试者 在12周的实验治疗期间，分别在1、3和6个时间点进行随访 月份。我们假设服用活性地昔帕明或舍曲林的受试者， 但不是安慰剂，遗嘱证据： 1.减少了MAMPH滥用的严重性，作为MAMPH的减少而运作 尿液GCMS定量及自报量和频度的应用 使用，因为增加了对MAMPH渴望的控制和延长了持续时间 在药物治疗中的禁欲和滞留。 2.增加对艾滋病医疗服务的利用，运作方式为 增加参与度、出勤率和遵守 艾滋病医疗护理的规定领域。 3.高危性行为和吸毒频率下降 随着#年的减少，与性行为有关的活动开始运作 不安全性行为和同时吸毒对性行为影响的自我报告 行为评估。

DESCRIPTION: (Applicant's Abstract) Methamphetarnine abuse in conjunction with sexual activity is now epidemic among homosexual and bisexual males. We propose an investigation of the efficacy of two promising putative stimulant abuse pharmacotherapies, desipramine and sertraline, as abstinence facilitation treatments for metharnphetamine (MAMPH) dependence in a sample of homosexual and bisexual males with symptomatic AIDS. The pharmacotherapies will be applied as adjunctive treatment linked to a medical care clinic for AIDS. The investigation will employ a placebo controlled, double-blind, random assignment, three cell parallel group design that will assess 120 subjects during 12 week's of experimental treatment, with follow-up at 1, 3 and 6 months. We hypothesize that subjects on active desipramine or sertraline, but not placebo, will evidence: 1. Decreased MAMPH abuse severity, operationalized as a decrease in MAMPH use on quantitative GCMS in urine and on self-reported amounts and frequency of use, as increased control over MAMPH craving and as increased durations of abstinence and retention in drug treatment. 2. Increased utilization of medical services for AIDS, operationalized as increases on measures of engagement attendance, and compliance with prescribed domains of AIDS medical care. 3. Decreased frequency of high risk sexual behaviors and of drug use in conjunction with sexual activity operationalized as decreases in self-reports of unsafe sexual behaviors and concurrent drug use on sexual behavior assessments.