OLFACTORY INFLUENCES ON PHYSIOLOGICAL PARAMETERS

描述：（改编自研究者摘要）：哺乳动物 一个个体发出的化学信号， 共特异性受体中的生理学（例如，青春期加速，发情 周期调节和从发情抑制中释放）称为引物 费洛蒙 激素对共特异性化学信号的反应通常通过 增加促黄体生成激素（LH）。引物样信息素效应 包括月经周期的长度和时间的改变 使用雄性或雌性腋窝分泌物提取物的连续应用， 女性 腋窝分泌物似乎是“最佳候选人”的人类气味源， 化学传播特性。 调查人员已经启动了一项 程序，以确定腋窝分泌物的化学性质， 开发一种可靠的方法来评估类信息素的化学成分 活动 该提案提供的数据表明， 男性腋窝提取物对女性志愿者的鼻区，影响 L.H.脉型研究人员将使用该生物测定法来指导 对活性腋窝提取物成分的分析研究。 在 此外，这项研究将有助于阐明神经内分泌机制， 在嗅觉调节月经周期中的作用 理解这一 机制可以提供洞察其他月经失调， 与LH脉冲的细微变化相关， 环境影响，如下丘脑性闭经和不孕症 因为黄体期不足 与此同时，调查人员将 继续研究腋窝的气味化学。 研究人员计划确定ASOB 1的结构，并检查ASOB 1的结构。 唾液和其他体液中发现的45 kDa蛋白质，以确定：（a）其 与顶浆分泌物ASOB 1结构相似，（B）是否具有3 M2 H 结合到它;和（c）是否由它和顶浆分泌apoD（ASOB 2）进行气味 在人类月经周期之后。

DESCRIPTION: (Adapted From The Investigator's Abstract): Mammalian chemical signals emitted by one individual which act to alter reproductive physiology in a cospecific recipient (e.g., acceleration of puberty, estrous cycle regulation and release from estrous suppression) are termed primer pheromones. Hormonal response to cospecific chemosignals often act by increasing luteinizing hormone (L.H). Primer-like pheromone effects in humans include an alteration of the length and timing of the menstrual cycle using serial applications of male or female axillary secretion extracts upon females. Axillary secretions appear to be the "best candidate" human odor source with chemical communicator properties. The investigators have initiated a program to determine the chemical character of axillary secretions and develop a reliable method to assess chemical constituents for pheromone-like activity. This proposal presents data which suggest that application of a male axillary extract to the nasal area of female volunteers, affects the pulse pattern of L.H. The investigators will employ this bioassay to guide an analytical study into the active axillary extract constituents. In addition, this study will help elucidate neuroendocrine mechanisms involved in olfactory modulation of the menstrual cycle. Understanding this mechanism may provide insight into other menstrual disorders which are associated with subtle alterations in LH pulsing and thought to be related to environmental influences such as hypothalamic amenorrhea and infertility due to an inadequate luteal phase. In parallel, the investigators will continue studies of axillar odor chemistry. The investigators plan to determine the structure of ASOB1 and examine the 45 kDa protein found in saliva and other body fluids to determine: (a) its structural similarity to apocrine secretion ASOB1, (b) whether it has 3M2H bound to it; and (c) whether odors carried by it and apocrine apoD (ASOB2) after the human menstrual cycle.