PROFILE BASED, INTERNET LINKED, OBESITY PREVENTION TRIAL

肥胖症及其并存现象日益普遍，以前的减肥/维持干预措施收效甚微，这说明有必要采取新的方法来预防肥胖症。围绝经期妇女超重和肥胖的风险并不高。在此期间，生理和行为因素导致能量消耗的变化，从而促进能量过剩和总脂肪和腹部脂肪的逐渐增加，通常会因瘦组织的丧失而加剧。因此，我们建议为超重的围绝经期妇女开发和测试一种创新的个性化减肥/维持计划，其驱动因素是对受试者的生物心理社会特征的频繁评估(允许对个体需求的及时干预响应)，并通过广泛使用新的通信技术(主要是互联网-CD-ROM混合包)来实现，这些技术在行为和生物学研究中基本上是未被探索的。为此，超重/肥胖的围绝经期妇女(年龄在45岁到55岁之间)在完成为期3个月的核心课程锻炼、饮食和认知行为治疗后，将被随机分为干预组(n=50)或对照组(n=50)。经过3个月的计算机培训过渡(仅限干预组)，干预(15个月)将仅通过互联网进行，实验室测量除外(干预组和对照组)。目标是增加身体活动(大约1500千卡/周)、健康饮食和适度限制卡路里并提供足够的营养，特别强调促进自我指导的行为。生物-心理-社会“减肥概况”将通过网站上的问卷进行监测，并用于个体化干预、对变化的需求作出反应，并评估其与双能x射线吸收测量法测量的体重和成分变化的关系。我们认为，互联网/网站技术是一种潜在的低成本和有效的手段，可以提供持续的教育、鼓励和社会支持，以促进持续的行为改变和减肥/维持。

The increasing prevalence of obesity and its co-morbidities and the limited success of previous weight loss/maintenance interventions argues the need for new approaches to prevent obesity. Peri-menopausal women are t high risk to develop overweight and obesity. Around that period, physiological and behavioral factors contribute to changes in energy expenditure which promote energy surfeit and progressive gain of total and abdominal fat, often exacerbated by loss of lean tissue Thus, we propose to develop and test an innovative individualized weight loss/maintenance program for overweight peri-menopausal women, driven by frequent assessment of subjects' biopsychosocial profiles (allowing timely intervention response to individual needs), and delivered through extensive use of new communication technologies (primarily and Internet-CD-ROM hybrid package) which have been largely unexplored in behavioral and biological research. To this end, overweight/obese peri-menopausal (aged 45 to 55 years) women will be randomized to intervention (n=50) or control (n=50) after completing a 3-month core curriculum exercise, diet, and cognitive- behavior therapy. After a 3 months transition with computer training (intervention group only), intervention (15 months) will proceed via the internet only, except for laboratory measurements (intervention and control groups). Increased physical activity (approximately 1500 kcal/week), healthy eating and modest calorie restriction with adequate nutrients will be targeted, with special emphasis on promotion of self-directed behavior. Biopsychosocial "weight loss profiles" will be monitored through questionnaires on the web site and used to individualize intervention, respond to change needs, and assess their relationship with changes in body weight and composition measured by dual energy x-ray absorptiometry. We contend the internet/web site technology represents a potentially low cost and effective means for providing the continuous education, encouragement and social support to foster sustained behavior change and weight loss/maintenance.