TOXICOLOGIC EFFECTS OF AIR POLLUTANTS ON LUNG DEFENSE

该项目涉及对单一和非生物燃料的毒理学影响的检查 反复暴露在硫酸雾、二氧化氮或臭氧中 肺的非特异性防御机制，以兔为动物 模特。研究的基本机制是反射性支气管收缩， 气管、支气管树和肺泡的粘液纤毛清除 巨噬细胞介导的呼吸区清除。净空是 在未服用镇静剂的动物中使用放射性标记的示踪剂气雾剂进行研究。 巨噬细胞的特殊功能将在体外进行检测 在活体暴露后。此外，肺的组织学分析。 将会进行组织移植。巨噬细胞和组织分析的结果将 关系到整体的通关效力。这项研究将提供 关于三种主要环境空气污染物在气候变化中的作用的信息 基本的肺防御；这种变化可能是早期的 进展为慢性阻塞性肺病。

This project involves examination of the toxicologic effects of single and repeated exposures to sulfuric acid mist, nitrogen dioxide, or ozone upon nonspecific defense mechanisms of the lung, using the rabbit as an animal model. The basic mechanisms examined are reflex bronchoconstriction, mucociliary clearance from the tracheobronchial tree, and alveolar macrophage-mediated clearance from the repiratory region. Clearance is studied in unsedated animals using radioactively tagged tracer aerosols. Specific functional aspects of macrophages will be examined in vitro following in vivo exposures. In addition, histological analyses of lung tissue will be performed. Results of the macrophage and tissue assays will be related to overall clearance effectiveness. This study will provide information on the role of three major ambient air pollutants in altering essential lung defenses; such changes may be early stages in the progression towards chronic obstructive lung disease.