HORMONE RHYTHMS: METABOLIC SIGNIFICANCE IN PSYCHIATRY

这是对ADMHA研究科学家奖的申请。在过去的九年里 我担任过I类和II类研究开发科学家多年 奖项。获得研究科学家奖将使我能够继续我的 心理神经内分泌学的研究项目，这些项目已经增长和 在过去的15年里发展起来的。这些项目包括内分泌 以及对快速循环的躁郁症药物的生化研究， 军事人群应激反应的神经内分泌研究及其基础 睡眠-内分泌研究描绘了昼夜节律和超常分泌物 前、后垂体腺、肾上腺和性腺的形态 正常人体内的荷尔蒙。后一项研究促成了我的博士论文 生理学研究，这是我第一类获奖的条件之一。我现在正在申请 我对精神病患者的基本内分泌学经验，特别是在 美国国立卫生研究院资助的严重内源性抑郁症的神经内分泌研究。这个 几种多肽和类固醇与睡眠相关的分泌模式 激素及其对TRH和LHRH刺激和地塞米松的反应 在治疗前、治疗中和治疗后确定抑制 原发性抑郁症，内源性亚型，按RDC分类。全 荷尔蒙分析正在我的实验室里进行。其他正在进行的项目 包括NIMH资助关于睡眠分期和地塞米松的研究 ONR资助的唾液和唾液在这些患者中的药代动力学比较 血清激素测定与实验室发育神经内分泌学 动物。我的辅助研究活动包括担任 神经内分泌学，在另外两本杂志的编辑委员会上，一 等待ADAMHA研究组的任命(第二次这样的经历)， 以及在研究协会中的领导角色。拥有一位研究科学家 获奖将允许我继续这些活动。

This is a request for an ADMHA Research Scientist Award. For the past nine years I have held Type I and Type II Research Scientist Development Awards. Receiving a Research Scientist Award will permit me to continue my research programs in psychoneuroendocrinology, which have grown and developed over the past 15 years. These programs have included endocrine and biochemical studies of rapidly cycling manic-depressives, neuroendocrine studies of stres in military populations, and basis sleep-endocrine studies delineating the circadian and ultradian secretion patterns of anterior and posterior pituitary and adrenal and gonadal hormones in normal men. The latter studies led to my PhD dissertation research in physiology, a condition of my Type I award. I now am applying my basic endocrinologic experience to psychiatric patients, especially in an NIMH-funded neuroendocrine study of severe endogenous depression. The sleep-related secretion patterns of several polypeptide and steroid hormones and their responses to TRH and LHRH stimulation and dexamethasone suppression are being determined before, during, and after treatment in primary major depressives, endogenous subtype, classified by the RDC. All hormone analyses are being done in my laboratory. Other current projects include an NIMH-funded study of sleep staging and dexamethasone pharmacokinetics in these patients, an ONR-funded comparison of saliva with serum hormone measures, and developmental neuroendocrinology in laboratory animals. My ancillary research activities include being Editor-in-Chief of Pschoneuroendocrinology, on the editorial boards of two other journals, a pending appointment to an ADAMHA study section (second such experience), and leadership roles in research societies. Having a Research Scientist Award will permit me to continue these activities as well.