HORMONE RHYTHMS: METABOLIC SIGNIFICANCE IN PSYCHIATRY

这是ADMHA研究科学家奖的申请。 过去九 多年来，我一直担任I型和II型研究科学家发展 奖 获得研究科学家奖将使我能够继续我的研究。 心理神经内分泌学的研究项目，这些项目已经发展， 在过去的15年里发展起来的。 这些项目包括内分泌 以及对快速循环的躁狂抑郁症患者的生化研究， 军事人群应激的神经内分泌研究及其基础 描述昼夜节律和超昼夜分泌的睡眠内分泌研究 垂体前叶、垂体后叶、肾上腺和性腺的模式 正常男性的荷尔蒙水平 后一项研究促成了我的博士论文 生理学研究，这是我获得I类奖的条件之一 我现在申请 我对精神病患者的基本内分泌经验，特别是在 NIMH资助的一项关于严重内源性抑郁症的神经内分泌研究。 的 几种多肽和类固醇睡眠相关分泌模式 激素及其对TRH和LHRH刺激和地塞米松的反应 在治疗前、治疗期间和治疗后， 原发性重度抑郁症，内源性亚型，由RDC分类。 所有 我的实验室正在进行激素分析 其他经常项目 包括NIMH资助睡眠分期和地塞米松的研究 这些患者的药代动力学，ONR资助的唾液与 血清激素测量和实验室发育神经内分泌学 动物 我的辅助研究活动包括担任主编， 神经内分泌学，在其他两个期刊的编辑委员会， 等待任命到ADAMHA研究部门（第二次此类经验）， 和研究协会的领导角色。 拥有研究科学家 我的奖励也会让我继续这些活动。

This is a request for an ADMHA Research Scientist Award. For the past nine years I have held Type I and Type II Research Scientist Development Awards. Receiving a Research Scientist Award will permit me to continue my research programs in psychoneuroendocrinology, which have grown and developed over the past 15 years. These programs have included endocrine and biochemical studies of rapidly cycling manic-depressives, neuroendocrine studies of stres in military populations, and basis sleep-endocrine studies delineating the circadian and ultradian secretion patterns of anterior and posterior pituitary and adrenal and gonadal hormones in normal men. The latter studies led to my PhD dissertation research in physiology, a condition of my Type I award. I now am applying my basic endocrinologic experience to psychiatric patients, especially in an NIMH-funded neuroendocrine study of severe endogenous depression. The sleep-related secretion patterns of several polypeptide and steroid hormones and their responses to TRH and LHRH stimulation and dexamethasone suppression are being determined before, during, and after treatment in primary major depressives, endogenous subtype, classified by the RDC. All hormone analyses are being done in my laboratory. Other current projects include an NIMH-funded study of sleep staging and dexamethasone pharmacokinetics in these patients, an ONR-funded comparison of saliva with serum hormone measures, and developmental neuroendocrinology in laboratory animals. My ancillary research activities include being Editor-in-Chief of Pschoneuroendocrinology, on the editorial boards of two other journals, a pending appointment to an ADAMHA study section (second such experience), and leadership roles in research societies. Having a Research Scientist Award will permit me to continue these activities as well.