EPIDEMIOLOGY OF CUTANEOUS CANCERS--A MODEL FOR HUMAN CARCINOGENESIS

三项基于人群的皮肤癌合作研究是 建议将重点放在紫外线，饮食因素， 生化标志物和其他已知或疑似流行病学 风险因素及其相互关系。 病例和对照组将 从亚利桑那州东南部的6个县获得。 两 的拟议研究将使用病例对照设计， 由病理学确诊的皮肤 1项研究中的基底细胞癌或鳞状细胞癌和定义的病例 通过病理学确诊的黑色素瘤， 第二项研究。 每起案件中， 这些县，按年龄、性别、民族血统和 地理区域，将使用随机数字选择作为对照 正在拨号 由于年龄和性别分布相似， 黑色素瘤和非黑色素瘤（即基底细胞和鳞状细胞 癌症）病例中，很大一部分人被选为 一项研究的对照预期匹配并用作 第二次病例对照研究的对照。 第三项拟议研究将采用前瞻性队列设计， 包括第一个病例中包括的所有非黑色素瘤病例- 上述对照研究加上增加的受试者有1个或多个 有过非黑色素瘤皮肤癌病史 队列受试者将接受 他们的非黑色素瘤皮肤癌经病理证实 完全切除，并将随访诊断为 随后的皮肤癌。 所有受试者将在研究期间接受访谈。 非黑色素瘤受试者也将在12个月时接受访谈 的间隔 将采集血液和组织标本， 在研究时为所有研究受试者处理和储存。 这些样本将储存起来，以便在一九八九年进行分析。 90（该项目的第4年），访谈后，数据已 分析了 样本分析将包括棕榈酸视黄酯， β-胡萝卜素和其他微量营养素 在访谈中获得的饮食摄入量数据。 四年 计划所有研究的总持续时间，包括分析和 准备手稿。

Three collaborative population based studies of skin cancer are proposed which will focus upon ultraviolet light, dietary factors, biochemical markers and other known or suspected epidemiologic risk factors and their interrelationship. Cases and controls will be obtained from the 6 counties of Southeastern Arizona. Two of the proposed studies will use a case-control design, with cases defined by a pathologically confirmed diagnosis of cutaneous basal or squamous cell carcinoma for one study and cases defined by a pathologically confirmed diagnosis of melanoma for the second study. For each case, 2 persons from the population of these counties, frequency matched by age, sex, ethnic origin, and geographic region, will be selected as controls using random digit dialing. Due to the similar age and sex distribution for melanoma and nonmelanoma (i.e. basal and squamous cell carcinoma) cases, a large proportion of persons selected as controls for one study are anticipated to be matched and used as controls for the second case-control study. The third proposed study will use a prospective cohort design and include all cases of nonmelanoma included in the first case- control study described above plus added subjects with 1 or more prior nonmelanoma skin cancers. Cohort subjects will have had their nonmelanoma skin cancer pathologically confirmed completely removed and will be followed for the diagnosis of subsequent skin cancers. All subjects will be interviewed at the time on study. Nonmelanoma subjects will also be interviewed at 12 month intervals. Blood and tissue specimens will be collected, processed and stored for all study subjects at the time on study. These specimens will be kept in storage for analysis during 1989- 90 (year 4 of this project) and after the interview, data has been analyzed. Analyses of specimens will include retinyl palmitate, beta-carotene and other micronutrients identified from analysis of dietary intake data obtained during interview. A four year total duration for all studies is planned and includes analysis and preparation of manuscripts.