Investigating spermatogonial stem cell allocation in the fetal testis

该项目旨在确定何时以及如何指定精原干细胞(SSCs)，以及体外干细胞使用的遗传途径是否也适用于体内的睾丸干细胞。该项目旨在提供对成体干细胞规范和调控机制的总体洞察。这项工作的预期实际成果将为动物(农业和濒危物种保护)和人类生育管理的新方法奠定基础。所获得的知识将使我们更广泛地了解干细胞生物学，并指导治疗动物和人类不孕不育或控制生育能力的努力。

This project aims to determine when and how spermatogonial stem cells (SSCs) are specified, and whether a genetic pathway that is used by in vitro stem cells is also employed, in vivo, by testicular stem cells. The project aims to deliver insight into the mechanisms of adult stem cell specification and regulation, in general. Intended practical outcomes of this work will underpin new methods for fertility management in animals (in agriculture and conservation of endangered species) and humans. Knowledge gained will inform our understanding of stem cell biology more broadly and guide efforts to treat infertility or control fertility in animals and humans.