FAMILY STUDIES OF CHILDHOOD PSYCHIATRIC DISORDERS

该项目研究了几个主要的儿童/青少年 精神疾病，每种现有证据均提示 家族传播。正在调查的障碍是：注意力 伴有和不伴有多动的缺陷障碍;情绪障碍，以及 儿童期精神分裂症 该方案项目有4个关于这些疾病的总体目标： 1)阐明遗传因素在其病因学中的作用; 2） 根据家系确定诊断疾病学和分类 遗传数据; 3）检查某些可能的病理生理学 机制;以及4）确定重要的心理和社会 相互关联 项目1（“遗传分析”）是该方案的中心。这 项目利用其他项目收集的数据，并提供 数学、家庭和遗传分析。 其他6个项目 专注于特定的疾病，并测试特定的项目内 目前理论上的重要性。 组织这些 作为计划项目的单独项目确保了 科学家的多样性和复杂所需的专业 收集数据。 此外，每个项目都有假设， 需要家族遗传学研究的测试。 项目的核心设施最大限度地提高了 通过提供中央综合资源进行研究： 招募、诊断和（临床和实验室）评估 主题;建立和维护数据库;统计数据 分析。 各种项目中的诊断将使用传统的 症状群、诊断方案（如DSM），此外， 评估措施被认为更直接地反映了病理生理学 在疾病（例如，注意力测试）。 因此，项目框架 允许同时进行横断面和家庭研究 评估诊断之间症状重叠的程度，沿着 个别研究检查这些诊断的假定底物。

This Program Project studies several major childhood/adolescent psychiatric disorders, each with existing evidence suggestive of familial transmission. The disorders under investigation are: attention deficit disorder with and without hyperactivity; mood disorder, and childhood onset schizophrenia. The Program Project has 4 overall aims with regard to these disorders: 1) to clarify the role of genetic factors in their etiology; 2) to define the diagnostic nosology and classification in the light of family genetic data; 3) to examine certain possible pathophysiological mechanisms; and 4) to identify significant psychological and social correlates. Project 1 ("Genetic Analysis") is the center of the Program. This project utilizes data assembled by the other projects and provides mathematical, family and genetic analyses. The other 6 projects each focuses on specific disorders, and test specific within-project hypotheses of current theoretical importance. The organization of these separate projects as a Program Project insures the collaboration among the diversity of scientists and specialties necessary for the complex data collection undertaken. In addition, each project has hypotheses to test which require family genetic studies. The Core facilities of the Program Project maximize the efficiency of the research studies by providing central consolidated resources for: recruitment, diagnosis and (clinical and laboratory) assessment of subjects; establishing and maintaining data bases; and statistical data analyses. Diagnosis in the various projects will use traditional symptom clusters, diagnostic schemes such as DSM, and, in addition, assessment measures thought to more directly reflect the pathophysiology of the disorders (e.g., attentional tests). Thus, the Project framework permits simultaneous work on cross-sectional and family studies assessing the degree of symptom overlap across diagnoses along with individual studies examining the putative substrates of these diagnoses.