DEVELOPMENTAL ADAPTATION

儿科科学的标志是认识和补救那些不利的 基因和环境的影响会限制孩子的能力 以实现他/她最大的潜力。目标将需要成功 培训一批能够带来兴奋的儿科医生/科学家 和现代基础科学技术来提高我们对 正常发育事件和那些发育异常的事件 继续导致受伤、残疾和死亡。 这个应用程序的主题是发展性适应，具有独特的 与儿科相关。它涵盖了正常的发育生物学和 胎儿和儿童对侮辱发生的生理和适应 在发展时期。该项目的教职员工将包括 小儿科的一名初级教员与 由儿科医生/科学家组成的机构范围内的资源教员， 细胞和分子生物学家、神经学家和遗传学家， 与主要教职员工一起，将指导年轻的调查人员 由该计划选择支持。 被选中参加的四名年轻教职员工的研究环境 在我们的计划中将由计划咨询委员会仔细审查 充分认识到环境的质量将 最终决定了项目的成功。小学的实验室 耶鲁大学儿科中心儿科资源教研室 分子医学等科室将作为教研室所在地 研究开发。研究体验将通过 将提供持续论坛的教育和方案部分 用于青年教师的研究互动。我们已经定义了一个核心 将支持组织培养和转基因小鼠需求的实验室 对于一些我们已经确认为有潜力的调查人员 这个项目的候选人。这些特定的核心设施与 小学和资源学院的资源将提供广泛的 支持这一计划的科学调查光谱。 小儿科提供了大量的培训机会 包括几笔NIH资助的培训赠款，NIH资助的儿童 临床研究中心和高度互动的研究导向型教师 耶鲁大学的CHRC将提供一个出色的互动环境， 合作，以及年轻教员的持续科学发展。

The Hallmark of Pediatric science is to recognize and remedy those adverse genetic and environmental influences that can limit the capacity of a child to achieve his/her greatest potential. The goal will require the successfu training of a cadre of pediatrician/scientists who can bring the excitement and technology of modern basic science to improve our understanding of normal developmental events and to those abnormalities of development that continue to result in injury, handicaps and death. The theme of this application, Developmental Adaptation, has unique relevance to Pediatrics. It encompasses normal developmental biology and physiology and the adaptation of the fetus and child to insult occurring during the period of development. The faculty of the program will include a primary faculty in the Department of Pediatrics working closely with an institution-wide resource faculty comprised of pediatrician/scientists, cellular and molecular biologists, neuroscientists, and geneticists who, together with the primary faculty, will guide the young investigators selected for support by this program. The research environment for the four young faculty selected to participate in our Program will be carefully reviewed by the program Advisory Committee with the full recognition that the quality of the environment will ultimately define the success of the program. Laboratories of the Primary and Resource Faculty in the Department of Pediatrics, Yale Center for Molecular Medicine and other departments will serve as the sites for facult research development. The research experience will be enhanced by the educational and programmatic components that will provide an ongoing forum for research interaction of young faculty. We have defined a core laboratory that will support the tissue culture and transgenic mouse needs for a number of investigators whom we have identified as being potential candidates for this program. These specific core facilities combined with the resources of the Primary and Resource Faculty will provide a broad spectrum of scientific investigation to support this program. The Department of Pediatrics provides a large base of training opportunitie including several NIH supported training grants, an NIH funded Children's Clinical Research Center and a highly interactive research oriented faculty A CHRC at Yale will provide an outstanding milieu for interaction, collaboration, and the continued scientific development of young faculty.