PSYCHOSOCIAL SUPPORT & INTENSIVE CANCER TREATMENT

癌症是老年人的一个主要健康问题。尽管取得了进展，但 癌症的治疗和选择，一些老年人可能没有机会 因社会因素参与癌症治疗。国内外最新研究进展 急性白血病和小细胞肺癌的治疗已经清楚地表明 通过偶尔的长期治疗改善生存时间和质量 幸存者。完全缓解的患者显著地 提高存活率，无论年龄大小；然而，早期死亡与以下因素有关： 毒性，共病条件，或其他因素，可能在 限制能够完全缓解的老年患者的数量。 由于社会环境与身心健康息息相关， 目前的研究旨在描述当时的社会支持 初步治疗，并随后确定这种载体是否 与治疗、毒性或治疗结果有关的。身份识别 在未来的研究中，这些社会支持变量可以用来预测 治疗结果，以开发治疗分层，或设计， 改善治疗的干预措施(例如，增加缺失的支架) 选择。小细胞肺癌或急性白血病患者代表 UMCC的两个最大的患者群体和治疗结果 可以在拟议的项目期内观察到。的强烈程度 这两种疾病的治疗方法都是让患者定期就诊。 促进数据收集。因此，所有患有这两种疾病的患者 将参加目前对社会支持影响的评估 关于疾病的治疗和结果。这些病人将接受治疗 允许标准化的当前标准UMCC治疗方案 治疗和支持性护理。这些因素是极其重要的 因为它们最大限度地减少了可能对 病人的死亡率。调查人员和支持人员已经 在这些疾病的治疗和设计方面的专业知识 社会支助工具的执行情况分析 在这笔赠款中使用。这些工具包括病例组合和严重程度 科恩社会支持量表的维度--Horn的测评方法 和老年美国人资源调查问卷。这些仪器将是 通过收集人口统计和临床数据以及 治疗前预后因素的评估。所有统计数据 预测表明，案例应计利润将足以分析 收集变量，以便成功完成项目 预计在供资时间范围内。

Cancer is a major health problem among the elderly. Despite advances in cancer treatment and options, some elderly may not have the opportunity to participate in cancer treatment because of social factors. Advances in the treatment of acute leukemia and small cell lung cancer have clearly shown improvement in duration and quality of survival with occasional long-term survivors. Patients who achieve complete response have significantly improved survival regardless of age; however, early deaths related to: toxicities, comorbid conditions, or other factors, may be important in limiting the number of elderly patients who can achieve complete response. Since the social environment is closely tied to physical and mental health, the current study is designed to characterize social supports at the time of initial treatment and, subsequently, to determine if such supports are related to treatment, toxicity, or treatment outcome. The identification of such social support variables may, in future studies, be used to predict treatment outcomes, to develop treatment stratification, or design, interventions (e.g., adding missing supports) to improve treatment options. Patients with small cell lung cancer or acute leukemia represent the two largest patient groups at UMCC and have treatment outcomes which can be observed within the proposed project period. The intensity of treatment for both diseases is such that the patients make regular visits facilitating data collection. Thus, all patients with these two diseases will be enrolled in the current evaluation of the impact of social support on disease treatment and outcome. These patients will be treated on current standard UMCC treatment protocols allowing for the standardization of treatment and supportive care. These factors are of extreme importance to the current proposals since they minimize variables which can contribute to patient mortality. The investigators and support personnel have expertise in the treatment of these diseases as well as the design implementation analysis of the social support instruments which will be used in this grant. These instruments include the case mix and severity assessment method of Horn, the Dimensions of Social Support Scale by Cohen and the Older Americans Resources questionnaire. These instruments will be complemented by the collection of demographic and clinical data as well as an assessment of pretreatment prognostic factors. All statistical projections suggest that case accrual will be sufficient to analyze the variables collected so that successful completion of the project is anticipated within the funding time frame.