AGE, HYPERTENSION, AND INTELLECTIVE PERFORMANCE

这个项目的目的是继续研究，使我们能够 更好地了解高血压对WAIS和 神经心理测验随着年龄的增长而测量。延续我们的 正在进行的纵向研究将使我们能够1)跟踪研究对象 测试两次，为期六年(时间3测试)；2)执行 对第一次测试的受试者进行时间2(后续)测试 在我们目前的研究资助中；3)扩大我们的研究项目的数量 整体横断面设计，使我们可以获得统计力量 对于检查血浆肾素活性的影响是必要的， 抗高血压药物、首次试验的年龄、持续时间 高血压症状和血压水平对表现的影响。而当 目前的受试者数量可以评估这些项目的主要影响 变量，它们不允许我们在交互中评估这些变量 年龄和高血压状况(正常血压与高血压)。一 这一领域的大多数研究的普遍失败是数量不足 主题，这一失败只能通过坚持不懈和持续的努力来弥补 在受控条件下收集数据。另一个目标是 继续收集横断面数据的提法是 年龄/年龄相差六年的队列(使用的跟踪时间段 在我们的纵向研究中)。我们目前的纵向和纵向的结果 横断面研究并不一致。横断面数据 显示高血压患者和高血压患者之间更夸张的表现差异 血压正常的年轻人比年长的受试者，而我们的纵向 研究表明，情况恰恰相反。然而，横截面的比较 纵向结果是无效的，因为年龄差异 我们的横截面样本比我们的 纵向随访。

The purpose of this project is to continue studies which are allowing us to obtain a better understanding of the effects of hypertension on WAIS and neuropsychological test measures with advancing age. Continuation of our ongoing longitudinal studies will allow us to 1) follow subjects, already tested twice, for an additional six years (Time 3 testing); 2) perform Time-2 (follow-up) testing on subjects that were tested for the first time during our present research grant; 3) expand the number of subjects in our overall cross sectional design so that we may obtain the statistical power necessary for examinations of the influence of plasma renin activity, antihypertensive medications, age at initial testing, duration of hypertensive symptoms, and blood pressure levels, on performance. While present numbers of subjects allow evaluations of main effects for these variables, they do not permit us to evaluate these variables in interaction with age and hypertensive status (normotensive versus hypertensive). One universal failing of most all studies in this area is inadequate numbers of subjects, a failure that can only be remedied by persistent and continuous collection of data under controlled conditions. A further objective of continued collection of cross sectional data is the formulation of age/cohorts differing in age by six years (the follow-up time period used in our longitudinal studies). The results of our present longitudinal and cross sectional studies are not in agreement. Cross sectional data indicate more exaggerated performance differences between hypertensives and normotensives for younger than for older subjects while our longitudinal studies indicate just the opposite. However, comparison of cross sectional and longitudinal results are not valid because age differences are considerably larger for our cross sectional sample than for our longitudinal follow-up.