STRUCTURE OF ANTIBODY MOLECULES AND CELL MEMBRANES

本研究计划预计将研究三个主要领域。 a）细胞运动性和趋化性的分子机制将被进一步研究。 探索，特别注意插入新的膜 作为细胞关键特征的细胞前缘质量 扩展名. 此外，针对关键细胞表面的单克隆抗体 将寻找涉及趋化性和细胞运动性的组分。 B）加帽和相关细胞的分子机制 表面-细胞骨架的相互作用将被调查，重点放在一个 我们生产的单克隆抗体似乎是针对 与肌动蛋白微丝相关的整合蛋白， 细胞膜。 c）参与自然杀伤细胞的细胞毒性的细胞内事件 和细胞毒性T淋巴细胞（CTL）将进一步探索在一个系统中， 涉及受感染的靶细胞的CTL的限制性识别 淋巴细胞性脉络丛脑膜炎病毒（LCMV），与细胞的性质 从靶细胞到效应细胞的表面信号传导事件将被 探讨了

Three major areas of study are projected in this research program. a) The molecular mechanisms of cell motility and chemotaxis will be further explored, with particular attention paid to the insertion of new membrane mass into the leading edge of a cell as a critical feature of cell extension. In addition, monoclonal antibodies directed to key cell surface components involved in chemotaxis and cell motility will be sought for. b) The molecular mechanisms involved in capping and related cell surface - cytoskeletal interactions will be investigated, focusing on a monoclonal antibody we have produced that appears to be directed to an integral protein that is associated with actin microfilaments underlying the cell membrane. c) The intracellular events involved in cytoxicity by natural killer cells and cytotoxic T lymphocytes (CTL) will be further explored in a system involving restricted recognition of CTL of target cells infected with lymphocytic choriomeningitis virus (LCMV), with which the nature of cell surface signalling events from the target cell to the effector cell will be explored.