AGE-RELATED ERP MEASURES IN ALZHEIMER'S DISEASE

事件相关脑电位（ERP）和性能指标将 可能患有阿尔茨海默病（PAD）的患者记录，年龄- 匹配正常对照。 该提案的主旨是评估 外显和内隐记忆测试的表现， 控制设计，试图揭示生理 PAD中记忆缺陷的基础在行为研究中报告， 文学 提出了三个实验：1）第一个要求 我问PAD受试者与年龄匹配的对照者有何不同（行为上 和关于ERP）的方式，他们处理图片和 在线词汇输入，以及他们记忆和检索的方式 在隐式（片段完成）和显式（识别）期间的这种输入 测试; 2）第二个目的是评估编码的充分性 研究中的操作。 定向任务将用于操纵编码 活动 研究时的ERP活动将通过定向单独计算 任务，作为后续词干完成（隐式）和线索的函数 回忆（外显）表现。 该活动（即，ERP“记忆 效果”）预期在各组之间不同， 编码操作中的差异; 3）第三个试图确定 事件相关电位和行为重复效应会受到重复次数的调制 项目的重复（即，它的“记忆强度”）在PAD中类似， 年龄匹配的对照组。 在之前实验的基础上， 记忆力只会受到隐性测试，重点是记忆力。 在 一般情况下，还预计ERP旧/新的振幅 重复效应将反映在线期间启动的程度， 延迟记忆任务 将从几个头皮位置记录ERP 为了确定头皮分布，通过暗示， 它们的颅内发生器在各组之间存在系统性差异。 这些数据将与年龄相关的记忆病理变化有关 功能及其生理基础。

Event-related brain potentials (ERPs) and performance measures will be recorded from patients with probable Alzheimer's disease (PAD), and age- matched normal controls. The main thrust of the proposal is to assess performance on explicit and implicit tests of memory in carefully controlled designs, in an attempt to uncover the physiological underpinnings of memory deficiencies in PAD reported in the behavioral literature. Three experiments are proposed: 1) the first asks the question how do PAD subjects differ from age-matched controls (behaviorally and with respect to ERPs) in the ways in which they process pictorial and lexical input on-line, and the ways in which they remember and retrieve such input during implicit (fragment completion) and explicit (recognition) testing; 2) the second is aimed at assessing the adequacy of encoding operations at study. Orienting task will be used to manipulate encoding activity. ERP activity at study will be computed, separately by orienting task, as a function of subsequent stem completion (implicit) and cued recall (explicit) performance. This activity (i.e., the ERP "memory effect") is expected to differ between the groups as a function of differences in encoding operations; 3) the third seeks to determine if the ERP and behavioral repetition effect will be modulated by the number of repetitions of an item (i.e., its "memory strength") similarly in PAD and age-matched control subjects. In constrast to the previous experiment, memory will only be tested implicitly, and the focus is on retention. In general, it is also expected that the amplitude of the ERP old/new repetition effect will reflect the magnitude of priming during on-line and delayed memory tasks. ERPs will be recorded from several scalp placements in order to determine whether scalp distributions and, by implication, their intracranial generators, differ systematically between the groups. The data will be relevant to age-related pathological changes in memory function, and their physiological underpinnings.