13TSB_SynBio Enhanced discovery and scalable synthesis of therapeutic cyclic peptides

天然产物通常具有非常理想的生物和材料特性。在未来将会有巨大的压力来生产经济上有价值的材料，同时大大减少对环境的影响。这意味着英国的工业生物技术部门（与制药行业相关，但与制药行业不同）有一个利用世界一流科学的绝佳机会。该提案将一流的学术科学与创新小公司Ingenza的独特专业知识联系起来。该项目的主要目标是开发一种细菌系统（细胞工厂），用于大量生产新型可定制和高度修饰的环肽。环肽被发现是抗生素、抗癌剂、激素治疗和免疫系统调节剂。除了它们的直接药用作用外，它们也是研究生物过程的非常有用的工具。作为工具，这第二个作用尚未得到充分开发，仅仅是因为天然产物很难制造出足够的量。提出的工作将通过提供一个即插即用的系统来解决这些问题，在这个系统中，可以简单快速地对“细胞工厂”进行改变，以有效的规模生产大量的环状肽。

Natural products often have very desirable biological and material properties. In the future there will be immense pressureto produce economically valuable materials with much reduced environmental impact. This means the IndustrialBiotechnology sector (which is related to, but distinct from the Pharmaceutical Industry) in the UK has a golden opportunityto harness world class science. This proposal links first class academic science with unique expertise available in aninnovative small company, Ingenza. The main aim of the project is to develop a bacterial system (cell factory) for theproduction of novel customizable and highly modified cyclic peptides in significant quantities. Cyclic peptides are found asantibiotics, anticancer agents, in hormone therapy and in immune system modifying agents. In addition to their directmedicinal role, they are also very useful tools in studying biological processes, this second role, as tools, isunderdeveloped simply because natural products are hard to make in sufficient amounts. The proposed work will solvethese problems by providing a plug 'n' play system in which changes can be made simply and quickly to the 'cell factory' toproduce a vast array of cyclic peptides at a useful scale.