CANCER EPIDEMIOLOGY OF THE MIGRANT JAPANESE IN HAWAII

8,006名日本血统的男性，出生于1900年至1919年， 居住在瓦胡岛的人，在流行病学的基础上进行了检查 从1965年到1968年的研究。丰富的饮食、社交、个人和 实验室信息是从这些人那里获得的。自考试以来， 在我们的前瞻性研究中，我们已经确定了96例胃病 癌症，结肠癌90例，肺癌85例，前列腺癌72例，癌症57例 直肠，31个膀胱，28个胰腺，总共 459起癌症事件。在接下来的五年里，我们预计将确定 本院新增303例常见癌症病例 监控网络。根据过去收集的血清样本和 广泛的流行病学数据，特别是在饮食和营养领域， 我们建议做以下工作：1)确定是否存在关联 膳食脂肪、膳食纤维、酒精摄入量或血清维生素A水平 大肠癌；2)确定饮食中的亚硝酸盐，盐，蔬菜， 水果或特定的维生素与胃癌有关；3)确定 饮食、激素和其他与临床前列腺癌相关的因素 癌症；4)调查饮食和血清维生素A的关系，以及 酒精与肺癌；5)确定胰腺癌和肺癌的危险因素 膀胱癌；6)测定血清维生素A的相关性 和E为常见的上皮性癌。我们还建议在以下方面进行研究 结肠镜检查对象有无腺瘤性息肉，这是一个先兆 结肠癌的病变，将在超过100的消耗量上进行比较 不同的饮食项目。将进行一项类似的研究，以确定饮食 肠化生(胃的前驱病变)的相关因素 胃镜检查对象中的癌症)。这项提议的重点是 更好地了解与常见癌症相关的风险因素， 从而为实践的最终发展做出贡献 可以减少这些疾病发病率的干预措施。这个 流行病学、病理学、生物统计学和营养学学科 整合到这个项目中。

Eight thousand and six men of Japanese ancestry, born from 1900-1919 and residing on the island of Oahu, were examined in an epidemiologic-based study from 1965 to 1968. A wealth of dietary, social, personal, and laboratory information was obtained from the men. Since the examination, we have identified in our prospective study 96 incident cases of stomach cancer, 90 of the colon, 85 of the lung, 72 of the prostate, 57 of the rectum, 31 of the urinary bladder, and 28 fo the pancreas for a total of 459 incident cancer cases. Over the next five years we expect to identify an additional 303 incident cases of these common cancers with our hospital surveillance network. With the past collection of sera samples and extensive epidemiologic data, especially in the area of diet and nutrition, we propose to do the following: 1) determine if there is an association of dietary fat, dietary fiber, alcolol intake or serum vitamin A levels with large bowel cancer; 2) determine if dietary nitrites, salt, vegetables, fruits or specific vitamins are related to stomach cancer; 3) identify dietary, hormonal and other factors associated with clinical prostate cancer; 4) investigate the association of dietary and serum vitamin A, and alcohol with lung cancer; 5) identify risk factors for pancreatic and urinary bladder cancer; 6) determine the association of serum vitamins A and E with common epithelial cancers. We also propose to do a study in which colonoscopy subjects with and without adenomatous polyps, a precursor lesion of colon cancer, will be compared in their consumption of over 100 different dietary items. A similar study will be done to identify dietary factors related to intestinal metaplasia (a precursor lesion of stomach cancer) among gastroscopy subjects. This proposal is focused towards a better understanding of the risk factors associated with common cancers, and thereby would contribute to the ultimate development of practical interventions which could reduce the incidence of these diseases. The disciplines of epidemiology, pathology, biostatistics and nutrition are integrated into this project.