UK Veterinary Vaccinology Network

据估计，英国畜牧业（包括牛、猪、羊和家禽）的年产值约为100亿英镑;仅家禽就达40亿英镑（全球850亿英镑）。养殖鱼类的价值每年超过10亿英镑。全球通过疫苗接种根除牛瘟每年可能为非洲经济节省约10亿英镑。据估计，2007年快速部署的蓝舌病疫苗仅在2008年就为英国经济节省了约5亿英镑。通过开发针对广泛传播的传染病的新疫苗，英国畜牧业在改善动物福利和经济表现方面具有巨大潜力。地方病和外来病是新的控制方法的重要目标。例如，牛分枝杆菌代表了畜牧业目前难以解决的问题和疫苗开发的主要挑战。口蹄疫病毒是英国牲畜的持续威胁，现有疫苗的缺点限制了它们在地方性感染国家和英国爆发期间的有效性。在开发针对各种病原体的疫苗方面存在一些经常性的挑战，例如，鉴定保护性抗原，特别是针对大型复杂病原体的保护性抗原，确定保护相关性，了解最有效的抗原递送方法，并与此相关的刺激长期保护性免疫反应。该网络将汇集具有广泛技能和经验的科学家，建立团队来解决这些难题。兽医疫苗学网络将提供应用最新技术的机会。基础科学的发展，以加强对兽医疾病的控制，例如，保护性免疫反应的转录组学分析，鉴定T细胞和B细胞表位的高通量方法以及抗原递送平台。

The UK livestock industry including cows, pigs, sheep and poultry is estimated to have an annual value of ~£10bn; poultry alone is £4bn (£85bn globally). The value of farmed fish is in excess of £1bn per annum. Global eradication of rinderpest using vaccination probably saves the economies of Africa ~£1bn per annum. The rapid deployment of vaccines to control bluetongue in 2007 is estimated to have saved the UK economy ~£0.5bn in 2008 alone.There is huge potential to improve animal welfare and economic performance of the UK livestock industries by developing new vaccines for widespread infectious diseases. Endemic and exotic diseases are important targets for new control methods. For example, Mycobacterium bovis represents a currently intractable problem for the livestock industry and a major challenge for vaccine development. Foot-and-mouth disease virus is a constant threat to UK livestock and the shortcomings of the current vaccines limit their usefulness in endemically infected countries and during an outbreak in the UK.There are some recurrent challenges in developing vaccines for a wide range of pathogens, for example, identifying protective antigens especially for large complex pathogens, defining correlates of protection, understanding the most effective antigen delivery methods and related to this stimulating long term protective immune responses.The network will bring together scientists with a broad range of skills and experience to build teams to tackle these difficult problems.A veterinary vaccinology network will provide opportunities to apply the latest developments in basic science to enhance control of veterinary diseases, for example, transcriptomic analysis of protective immune responses, high throughput methods to identify T cell and B cell epitopes and antigen delivery platforms.