Mass spectrometry underpinning synthetic biology, industrial biotechnology and world class bioscience

生物质谱学的应用，特别是在蛋白质组学领域的应用，彻底改变了研究广泛的生物系统和回答重要问题的能力。生物质谱学具有核心重要性，目前支撑着广泛的生物系统中的各种研究。在化学和生物工程系(CBE)内，我们在质谱学方法应用方面拥有丰富的专业知识，并已使用这项技术回答了一些重要问题，包括：1)细菌如何防御病毒；2)光合作用中的蛋白质组织；3)我们如何优化细胞以生产重要产品。Q Exactive Plus仪器是市场上的新产品(2013年9月发布)，它为谢菲尔德大学及其研究伙伴提供了在研究活动范围内做出重大改变的机会。这些仪器的独特功能将加快我们的学术和工业研究。在我们强大的行业联系下，谢菲尔德大学最近成立了先进生物制造中心(ABC)。成立于化学和生物工程系，其目标是在英国生物产业内发展与生物制造和生物加工相关的跨学科研究。拟议的仪器将是一项关键资产；支持与生物制造和生物工艺开发相关的研究，并将支持目前由BBSRC资助的广泛研究组合，展示设备的巨大价值。

The application of biological mass spectrometry, in particular in the field of proteomics has revolutionised the ability of study a wide range of biological systems and answer important questions. Biological mass spectrometry is of central importance and currently underpins a diverse range of studies, across a wide range of biological systems. Within the Department of Chemical and Biological Engineering (CBE) we have significant expertise in the application of mass spectrometry approaches and have used this technology to answer important questions including; 1) how bacteria defend themselves from viruses 2) protein organisation in photosynthesis 3) how can we optimise cells to produce important products.The Q Exactive Plus instrument is new to market (released Sept 2013) and provides the opportunity for the University of Sheffield and it's research partners to make a step-change in the scope of research activities. The instruments unique features will accelerate our academic and industrial research.Underpinning our strong industry connections, the University of Sheffield has recently established an Advanced Biomanufacturing Centre (ABC). Arising from the Dept of Chemical and Biological Engineering, the aim is to develop interdisciplinary industrially-relevant research for biomanufacturing and bioprocessing within the UK bioindustry. The proposed instrument will be a critical asset; underpinning research associated with biomanufacturing and bioprocess development and will underpin an extensive portfolio of current BBSRC funded research, demonstrating the huge value of the equipment.