EPIDEMIOLOGY OF DRUG ABUSE & SPONTANEOUS ABORTIONS

建议的分析将加深我们对可能的 延长部分易滥用药物的生殖效应 已知染色体自然流产的观察 特点。母亲接触大麻、海洛因、 美沙酮、可卡因、安定和苯丙醇胺对染色体的影响 正常自然流产和染色体异常自然流产 各种类型的流产(如三体、单体X、三倍体)将 评估过了。此外，父亲吸食大麻与 自然流产，由流产和母体的染色体组型来定义 吸食大麻会导致胎儿宫内发育迟缓和早产 接受检查。 这些数据来自流行病学、细胞遗传学和病理学的综合研究 对自然流产的研究。系统用药和药物使用 在12年内从一个连续的 因自然流产而寻求医院护理的妇女系列(病例)和 控制。总共有2700名自然流产妇女的数据 已知的核型和4600个对照可用于建议的 分析。这些已经收集的数据提供了一个独特的机会 扩大对药物滥用与生殖之间可能关系的观察。

The proposed analyses will deepen our understanding of the possible reproductive effects of selected drugs subject to misuse by extending observations to spontaneous abortions of known chromosomal characteristics. The relations of maternal exposure to marijuana, heroin, methadone, cocaine, diazepam and phenylpropanolamine (PPA) to chromosomally normal spontaneous abortions and to chromosomally abnormal spontaneous abortions of various types (e.g. trisomy, monosomy X, triploidy) will be assessed. In addition, the relation of paternal marijuana use to spontaneous abortion, defined by karyotype of the abortus, and of maternal marijuana use to intrauterine growth retardation and preterm delivery will be examined. The data derive from a combined epidemiologic, cytogenetic and pathologic study of spontaneous abortions. Systematic medication and drug use histories have been obtained over a 12 year period from a consecutive series of women seeking hospital care for spontaneous abortion (cases) and controls. In total data from about 2700 women with spontaneous abortions of known karyotype and 4600 controls are available for the proposed analyses. These already collected data provide a unique opportunity to extend observations on the possible relations of drug abuse to reproduction.