GENETIC EPIDEMIOLOGY OF MALIGNANT GLIOMA

恶性胶质瘤是我国最常见的原发恶性脑肿瘤 成年人，会使人虚弱并迅速致死。人们对此知之甚少 恶性胶质瘤的病因、家族史和不同的环境 危险因素在以前的流行病学研究中已经被提出。在……里面 此外，胶质瘤可能与一些家族中更常见的 癌症。还没有研究检查家族性和非家族性精神分裂症之间的相互关系 环境因素或测试的特定遗传模型可能会，在 第二部分，解释这些肿瘤的家族关系。在这项研究中， 病例(n=约450例)将是新诊断的成人 1991年7月1日至1994年6月30日期间经组织学证实的恶性胶质瘤 在旧金山地区的五个县。基于人口的控制(n= 大约450个)与年龄、性别、种族和电话相匹配 前缀将通过随机数字拨号获得。这项研究将 收集约5300人的详细家族病历 病例的一级亲属(父母、兄弟姐妹和子女)和 控制措施，以及关于职业、吸烟、饮酒、 含亚硝酸盐的饮食；水源；极低频率 电磁场暴露；染发剂的使用；个人医疗 病例和对照病史。发给成年亲属和 已故亲属的指定线人将评估医疗 亲属的利益状况和风险因素。相关的 将审查记录，以进一步验证报告的医疗记录 条件。分析将涉及五个目标：1)检验假设 患者的亲属比对照的亲属更有可能患有) 癌症(乳腺癌、肺癌、肾上腺癌或结直肠癌、肉瘤和 白血病尤其令人感兴趣)；b)脑瘤；和/或c)某些 神经系统状况；2)评估共享的贡献 家族性癌症的环境暴露或文化习俗 使用适合于聚类的Logistic回归技术进行聚类 样本数据；3)检验遗传的特定遗传模型 使用复杂隔离的患者家庭对疾病的易感性 分析；多个受影响家庭的扩展家系也将 评估；4)比较家庭人口学和环境风险 病例和对照中的因素；5)检查混杂和影响 用Logistic回归方法对这些因素进行修正 配对。

Malignant glioma, the most common primary malignant brain tumor in adults, is debilitating and rapidly fatal. Very little is known about the causes of malignant glioma; family history and diverse environmental risk factors have been suggested in previous epidemiologic studies. In addition, gliomas may be associated in some families with more common cancers. No study has examined the interrelationships of familial and environmental factors or tested specific genetic models that might, in part, explain the familial associations of these tumors. In this study, cases (n= approximately 450) will be adults newly diagnosed with histologically confirmed malignant glioma from 7/1/1991 through 6/30/1994 in five San Francisco area counties. Population-based controls (n= approximately 450) matched to cases for age, sex, race, and telephone prefix will be obtained through random-digit dialing. This study will collect detailed family medical histories for approximately 5300 first-degree relatives (parents, siblings, and children) of cases and controls, as well as information on occupation; smoking; alcohol use; diet containing nitrites; water sources; extremely-low-frequency electromagnetic field exposures; hair dye use; and personal medical history of cases and controls. Questionnaires to adult relatives and to designated informants of deceased relatives will assess medical conditions and risk factors of interest for the relatives. Pertinent records will be reviewed for further validation of reported medical conditions. Analyses will address five aims: 1) to test hypotheses that cases' relatives are more likely than controls' relatives to have had a) cancer (breast, lung, adrenal, or colo-rectal cancers, sarcoma, and leukemia are of particular interest); b) brain tumors; and/or c) certain nervous system conditions; 2) to evaluate the contributions of shared environmental exposures or cultural practices to familial cancer clustering using logistic regression techniques appropriate for cluster sample data; 3) to test specific genetic models of inherited susceptibility to disease in cases' families using complex segregation analyses; extended pedigrees of multiply affected families will also be evaluated; 4) to compare familial demographic and environmental risk factor in cases and controls; and 5) to examine confounding and effect modification among these factors using logistic regression methods for matched pairs.