Acute phase protein as biomarkers of disease in livestock and aquaculture

急性期蛋白（APP）是一种对感染和炎症引起的疾病作出反应时血液中浓度增加的蛋白质。测量血液中一种或多种APP的水平提供了有价值的诊断信息，特别是在人类医学中，这些APP测试已经有几十年的历史了。在动物中，所涉及的蛋白质和所发现的反应存在显著差异。我们的实验室是动物APP研究的领先中心，已经确定了每个物种中测量的最佳靶蛋白。该项目旨在开发快速、可靠和经济的分析方法，使APP的实验室测试可用于牛、鸡和鲑鱼生产，从而有利于动物的健康和福利。进一步的测试系统将被开发，这将允许兽医在农场访问时测试APP水平升高，帮助快速诊断和治疗。

Acute phase proteins (APP) are proteins which increase in concentration in blood in response to diseases caused by infection and inflammation. Measuring level of one or more APP in blood provides valuable diagnostic information, especially in human medicine where these tests for APP have been available for several decades. In animals there are significant differences in the proteins involved and in the responses found. Our laboratory is a leading centre for research into APP in animals and has identified the best target protein to measured in each species. This project is designed to develop rapid, robust and economic assays to enable laboratory tests for APP to be available for use in cattle, chicken and salmon production to the benefit of animal health and welfare. Further test systems will be developed, which will allow a veterinarian to test for raised APP levels on a farm visit, assisting in rapid diagnosis and treatment.