EFFECT OF DIETING ON ALCOHOL AND DRUG USE IN YOUNG WOMEN

横断面调查研究显示， 饮食失调和药物滥用的风险。动物 研究表明，药物摄入量增加可能是由食物引起的， 剥夺因为临床上明显的饮食失调 通常早于临床上显著的药物滥用的发作， 同时患有这两种疾病的患者人群，我们假设热量 年轻女性节食者的限制导致 药物滥用问题一项初步的纵向研究在 密歇根大学记录了节食的流行， 大一女生的暴食行为以及事件病例数 神经性贪食症的病例初探 PI进一步表明，有暴食行为史的女性， 在不符合DSM III R神经性贪食症标准的情况下， 比没有暴食行为的受试者更病态。 然而，没有数据存在的作用，节食和暴食行为发挥 在年轻女性中药物使用的发展。这样的调查 这种临床并发症的病因学需要 对节食严重程度、暴食行为和 在最大风险期间（即大学期间）使用药物。我们 建议对节食进行纵向三波调查研究 行为和物质使用在一个大的大学女生队列。结果 这项研究的结果应该能更好地定义节食和 行为，亚临床贪食行为，贪食症临床综合征 神经病和吸毒酗酒。有效性及临床意义 调查结果的一部分将由一个平行的、较小的 使用结构化访谈对重度节食者和非节食者进行的研究。的 数据将使我们能够：（1）使用节食和饮食行为的评估 确定未来滥用药物的高风险妇女;（2）设计 针对节食的年轻妇女的药物滥用预防计划 严重;（3）包括旨在减少节食的干预措施， 治疗女性药物滥用者。

Cross-sectional survey studies have shown very high rates of coprevalence of eating disorders and substance abuse in young women dieters. Animal studies have suggested that increased drug intake may be caused by food deprivation. Because the onset of clinically significant eating disorders usually antedates the onset of clinically significant substance abuse in patient populations with both disorders, we hypothesize that caloric restriction among young women dieters leads to increased development of substance abuse problems. A preliminary, longitudinal study conducted at the University of Michigan has documented the prevalence of dieting and bulimic behaviors in freshman women as well as the number of incident cases of bulimia nervosa occurring during the freshman year. A preliminary study by the PI shows further that women with a history of bulimic behaviors, but without meeting DSM III R criteria for bulimia nervosa, use substances in a more pathological manner than do subjects without bulimic behaviors. However, no data exist on the role that dieting and bulimic behaviors play in the development of substance use in young women. Such an investigation of the etiology of this clinical phenomenon of comorbidity would require the prospective assessment of dieting severity, bulimic behaviors, and substance use during a period of maximum risk (i.e. the college years). We propose to carry out a longitudinal, three-wave survey study of dieting behaviors and substance use in a large cohort of college women. The results of this study should better define the relationships between dieting behaviors, subclinical bulimic behaviors, the clinical syndrome of bulimia nervosa and drug and alcohol use. The validity and clinical significance of the survey results will be, in part, determined by a parallel, smaller study of severe dieters and nondieters using structured interviews. The data will allow us to: (1) use assessments of dieting and eating behavior to identify women at high risk for future substance abuse; (2) design substance abuse prevention programs targeted at young women who diet severely; and (3) include interventions designed to decrease dieting in the treatment of female substance abusers.