Using natural products to inspire discoveries in synthesis and biosynthesis

这个项目旨在了解海洋微生物生物合成不寻常的抗生素天然产物时发生的有机化学。在一种跨学科的方法中，将合成拟议的生物合成中间体，并针对从感兴趣的微生物中新分离的酶进行筛选。这将有助于阐明生物合成途径，并有助于发现可能在有机合成中广泛应用的新的化学酶反应活性。在该项目期间，还将发现非酶促的、预先发生的有机反应。这个项目的好处将是提高我们使用合成有机和化学酶相结合的方法合成潜在抗生素的能力。这可能会在未来产生有用的新抗生素。

This project aims to understand the organic chemistry that occurs in the biosynthesis of unusual antibiotic natural products by marine microorganisms. In an interdisciplinary approach, proposed biosynthetic intermediates will be synthesised and screened against newly isolated enzymes from the microorganisms of interest. This will allow the elucidation of biosynthetic pathways, and aid the discovery of new chemoenzymatic reactivity that may be broadly useful in organic synthesis. Non-enzymatic, predisposed organic reactions will also be uncovered during the project. The benefit of this project will be an improvement in our ability to synthesise potential antibiotics using a combined synthetic organic and chemoenzymatic approach. This could lead to useful new antibiotics in the future.