OZONE CHEMISTRY AND CHEMICAL CARCINOGENESIS

我们建议继续我们的研究，研究基本的 臭氧的有机和生物化学与相关的或怀疑的健康 效果。我们的总体目标是试图将这种基本的臭氧 化学：观察或预期环境健康影响的化学。 具体目标包括继续我们关于使用羰基的研究 氧化物作为单加氧酶(MOX)的模型。我们将继续 羰基氧化物与选择性多环芳烃反应的研究 碳氢化合物。我们还将扩展我们的建模研究，以包括 其他底物包括硫化物(作为胱氨酸残基的模型)， 酮和取代苯酚。底物的选择将是为了 进一步测试羰基氧化物作为MOX模型的适用性。这个 方法论将包括我们解决方案阶段研究的延续，如 以及气相模拟，以接近移动近似 环境条件。这些研究还将需要延长 我们的工作是确定臭氧和羰基的相对贡献 氧化物氧化。臭氧与环氧乙烷的关系 化学和化学致癌作用将进一步研究。

We propose to continue our studies on the relationship between the basic organic and biorganic chemistry of ozone and associated or suspected health effects. Our overall objective is to attempt to relate this basic ozone chemistry to observed or anticipated environmental health effects. Specific objectives include continuing our studies on the use of carbonyl oxides as models for the monoxygenase enzymes (MOX). We will continue to study the reactions between cabonyl oxides and selected polycyclic aromatic hydrocarbons. We will also extend our modeling studies to include additional substrates including sulfides (as models for cystine residues), ketones, and substituted phenols. The substrates will be chosen so as to further test the suitability of carbonyl oxides as MOX models. The methodology will include a continuation of our solution phase studies as well as gas phase analogs in order to move closely approximate environmental conditions. The studies will also require an extension of our work to determine the relative contributions of ozone versus carbonyl oxide oxidation. The relationship between ozone and carbonyl oxide chemistry and chemical carcinogenesis will be further investigated.