INTRAOPERATIVE MEASURES OF VOCAL FOLD YOUNGS MODULUS

这项研究将检验这样一种假设，即术中测量 人体声带的横向(水平)杨氏模数 改善单侧声门关闭不全的声学效果 声带麻痹。将对现有的原型设备进行修改并 用于测量声带的杨氏(弹性)模量 用特氟龙注射进行增强。在第一阶段的研究中，杨的 特氟隆注射后患者的模数将在 做手术。他们的发声功能将在手术后六周进行测试。 使用视频频闪测量和感知判断。在下一个 阶段，接受声带扩大术的患者将被随机分为 三组和他们的手术发声功能的结果将是 比较一下。在一组中，杨氏模量值与最大 第一阶段的成功手术结果将作为目标值 做手术。在第二外科手术组中，关节的杨氏模数 未受影响的声带将通过经气管刺激来确定 模拟正常的肌肉收缩和声门结构 发声。然后，该模数值将用作 受影响声带的声带增大程度。第三 组将作为对照组，在没有辅助的情况下进行手术 术中监测目标模数。要测量的设备 杨氏模数将作为术中评估的一个工具 通过比较不同的声学， 声门学、空气动力学、频闪录像和知觉测量 手术前后。

This study will test the hypothesis that intraoperative measurement of the transverse (horizontal) Young's modulus of the human vocal folds will improve phonosurgical results for glottal incompetence caused by unilateral vocal fold paralysis. An existing prototype device will be modified and used to measure Young's (elastic) modulus of the vocal folds during augmentation by Teflon injection. In the first phase of research, Young's modulus will be measured in patients after Teflon injection during their surgery. Their vocal function will then be tested six weeks after surgery using videostroboscopic measures and perceptual judgments. In the next phase, patients who receive vocal fold augmentation will be randomized into three groups and the results of their surgery on vocal function will be compared. In one group, the Young's modulus values associated with the most successful surgical results in Phase 1 will be used as target values during surgery. In the second surgical group, the Young's modulus of the unaffected vocal fold will be determined by using transtracheal stimulation to simulate normal muscular contraction and glottal configuration during phonation. This modulus value will then be used as the target for the degree of vocal fold augmentation of the affected vocal fold. The third group will serve as a control group and will have surgery without the aid of intraoperative monitoring of a target modulus. The device to measure Young's modulus will then be evaluated as a tool for intraoperative optimization of phonosurgical results by comparing various acoustic, glottographic, aerodynamic, videostroboscopic, and perceptual measures before and after surgery.