GROWTH FOLLOWING REPLACEMENT OF THE MANDIBULAR CONDYLE

这项研究将调查与长期增长和 颅面骨系统置换术后的适应性研究 猕猴生长中的下颌骨髁状突。上颌骨的生长和 自体下颌骨双侧髁突置换术后1) 下颌骨，2)骨，3)锁骨胸骨，4) 肋骨的肋骨软骨连接处将使用24个头影测量方法进行评估 幼年雌性猕猴作为实验对象。改编 在颞颌关节内，将进行两项组织学评估 移植后数年。 根据我们实验室以前的研究，以下是具体的 提出了假设或预测：1)双边替换 下颌骨髁状突与自体下颌骨髁状突将导致 下颌骨正常发育；2)双侧下颌骨置换 有植骨的髁状突会导致异常生长，导致 下颌骨生长发育不足；3)双侧下颌骨置换 肋骨与肋骨软骨交界处的髁突将导致 下颌骨发育不协调；4)双侧下颌骨置换 带锁骨胸骨末端的下颌骨髁突将导致 下颌骨持续和谐生长。 这项研究的结果将直接和立即影响到 颅面复合体生长发育的相关临床问题 下颌骨髁状突生长不足。这一结果将有助于 外科医生在选择为患者提供更好机会的移植时 当临床上用来替换有缺陷的人时，面部和谐生长 下颌骨髁状突。

This research will investigate the factors involved in long-term growth and adaptation of the craniofacial skeletal system following replacement of the mandibular condyle in growing Macaca mulatta. Growth of the maxilla and mandible after bilateral condylar replacement using autogenous 1) mandibular condyles, 2) bone, 3) sternal condyle of the clavicles, and 4) costochondral junction of ribs will be evaluated cephalometrically using 24 juvenile female Macaca mulatta as experimental subjects. Adaptations within the temporomandibular joints will be evaluated histologically two years following transplantation. Based upon previous studies in our laboratory, the following specific hypotheses, or predictions, are put forward: 1) bilateral replacement of the mandibular condyles with autogenous mandibular condyles will result in normal growth of the mandible; 2) bilateral replacement of the mandibular condyle with a bone graft will result in abnormal growth leading to a deficiency of mandibular growth; 3) bilateral replacement of the mandibular condyle with the costochondral junction of a rib will result in uncoordinated growth of the mandible, and; 4) bilateral replacement of the mandibular condyle with the sternal end of the clavicle will result in continued, harmonious growth of the mandible. The results of this study will have a direct and immediate impact on the related clinical problem of growth of the craniofacial complex following lack of growth of the mandibular condyles. The results will assist the surgeon in selecting a transplant which offers the patient a better chance of harmonious facial growth when used clinically to replace a defective mandibular condyle.